Trypanosoma cruzi stocks isolated from acute Chagas disease patients lead to lethal murine infection

被引：5

作者：

Oliveira, EC

Stefani, MMA

Campos, DE

Andrade, ALSS

Silva, SA

Rassi, A

Luquetti, AO

机构：

[1] UNIV FED GOIAS,DEPT IMUNOL,BR-74001970 GOIANIA,GO,BRAZIL

[2] UNIV FED GOIAS,DEPT SAUDE COLETIVA,BR-74001970 GOIANIA,GO,BRAZIL

[3] UNIV FED GOIAS,DEPT CLIN MED,BR-74001970 GOIANIA,GO,BRAZIL

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1997年 / 91卷 / 01期

关键词：

American trypanosomiasis; Chagas disease; Trypanosoma cruzi; experimental infection; mice;

D O I：

10.1016/S0035-9203(97)90381-3

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Ten Trypanosoma cruzi stocks recently isolated from patients in acute and chronic phases of Chagas disease were inoculated to susceptible (A/Sn) mice. The mice were inoculated with 10(4) trypomastigotes intraperitoneally and monitored for parasitaemia and mortality for up to 300 d. The results demonstrated that (i) T. cruzi stocks isolated from patients in the acute phase killed animals, while stocks from patients in the chronic phase did not; (ii) survival curves differed statistically among mice infected with lethal stocks, and (iii) parasite burden did not affect the mortality rate of mice.

引用

页码：25 / 27

页数：3

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