Optical resolution of baclofen via diastereomeric salt pair formation between 3-(p-chlorophenyl)glutaramic acid and (S)-(-)-alpha-phenylethylamine

被引：26

作者：

Caira, MR ^{[1
]}

Clauss, R ^{[1
]}

Nassimbeni, LR ^{[1
]}

Scott, JL ^{[1
]}

Wildervanck, AF ^{[1
]}

机构：

[1] FINE CHEM CORP, EPPINDUST, SOUTH AFRICA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1997年 / 04期

关键词：

D O I：

10.1039/a606037d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures of the diastereomeric salts of (R)-(+)- and (S)-(-)-3-(p-chlorophenyl)glutaramic acid with (S)-(-)-phenylethylamine have been determined by X-ray crystallography. Solubility and melting behaviours of the salts were analysed and correlated with their structural properties in the solid state, The (R)-(+)-3-(p-chlorophenyl)glutaramic acid was converted to (R)-(-)-baclofen via a Hofmann degradation (57% yield, 99.8% ee, enantiomeric excess).

引用

页码：763 / 768

页数：6

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