2D and 3D cell microarrays in pharmacology

被引：32

作者：

Gidrol, Xavier ^{[1
]}

Fouque, Brigitte ^{[1
]}

Ghenim, Lamya ^{[1
]}

Haguet, Vincent ^{[1
]}

Picollet-D'hahan, Nathalie ^{[1
]}

Schaack, Beatrice ^{[1
]}

机构：

[1] CEA, DSV, IRTSV, Lab Biopuces, F-38054 Grenoble 09, France

来源：

CURRENT OPINION IN PHARMACOLOGY | 2009年 / 9卷 / 05期

关键词：

D O I：

10.1016/j.coph.2009.05.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To analyze the phenotypic consequences of perturbing mammalian cells with drugs, there is an increasing need for systematic cell-based assays in an HTS format. Cell microarrays provide an attractive solution as they offer more than a simple miniaturization and mechanization of conventional microtiter plates. While standard monolayer two-dimensional culture conditions are poor mimics of the cellular environment in situ, microfabricated systems enable three-dimensional organotypic cell cultures and have the potential to provide biological insight not achievable before. This article compares different cell microarray formats and evaluates their potential use in the drug discovery process.

引用

页码：664 / 668

页数：5

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