Effect of hypoxia on human adipose-derived mesenchymal stem cells and its potential clinical applications

被引：65

作者：

Choi, Jane Ru ^{[1
]}

Yong, Kar Wey ^{[1
]}

Safwani, Wan Kamarul Zaman Wan ^{[1
]}

机构：

[1] Univ Malaya, Dept Biomed Engn, Fac Engn, Kuala Lumpur 50603, Malaysia

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2017年 / 74卷 / 14期

关键词：

Hypoxia; hASCs; Phenotype; Functionality; Clinical applications; Challenges; LOW-OXYGEN TENSION; CHONDROGENIC DIFFERENTIATION; ENDOTHELIAL-CELLS; STROMAL CELLS; EXPRESSION; SECRETION; SURVIVAL; GROWTH; PROLIFERATION; HIF-1-ALPHA;

D O I：

10.1007/s00018-017-2484-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human adipose-derived mesenchymal stem cells (hASCs) are an ideal cell source for regenerative medicine due to their capabilities of multipotency and the readily accessibility of adipose tissue. They have been found residing in a relatively low oxygen tension microenvironment in the body, but the physiological condition has been overlooked in most studies. In light of the escalating need for culturing hASCs under their physiological condition, this review summarizes the most recent advances in the hypoxia effect on hASCs. We first highlight the advantages of using hASCs in regenerative medicine and discuss the influence of hypoxia on the phenotype and functionality of hASCs in terms of viability, stemness, proliferation, differentiation, soluble factor secretion, and biosafety. We provide a glimpse of the possible cellular mechanism that involved under hypoxia and discuss the potential clinical applications. We then highlight the existing challenges and discuss the future perspective on the use of hypoxic-treated hASCs.

引用

页码：2587 / 2600

页数：14

共 89 条

[11] In Situ Normoxia Enhances Survival and Proliferation Rate of Human Adipose Tissue-Derived Stromal Cells without Increasing the Risk of Tumourigenesis [J].

Choi, Jane Ru ;

Pingguan-Murphy, Belinda ;

Abas, Wan Abu Bakar Wan ;

Yong, Kar Wey ;

Poon, Chi Tat ;

Azmi, Mat Adenan Noor ;

Omar, Siti Zawiah ;

Chua, Kien Hui ;

Xu, Feng ;

Safwani, Wan Kamarul Zaman Wan .

PLOS ONE, 2015, 10 (01)

[12] Impact of low oxygen tension on stemness, proliferation and differentiation potential of human adipose-derived stern cells [J].

Choi, Jane Ru ;

Pingguan-Murphy, Belinda ;

Abas, Wan Abu Bakar Wan ;

Azmi, Mat Adenan Noor ;

Omar, Siti Zawiah ;

Chua, Kien Hui ;

Safwani, Wan Kamarul Zaman Wan .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 448 (02) :218-224

[13]

Das R, 2010, TISSUE ENG PART B-RE, V16, P159, DOI [10.1089/ten.teb.2009.0296, 10.1089/ten.TEB.2009.0296]

[14] Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement [J].

Dominici, M. ;

Le Blanc, K. ;

Mueller, I. ;

Slaper-Cortenbach, I. ;

Marini, F. C. ;

Krause, D. S. ;

Deans, R. J. ;

Keating, A. ;

Prockop, D. J. ;

Horwitz, E. M. .

CYTOTHERAPY, 2006, 8 (04) :315-317

[15] Suction assisted liposuction does not impair the regenerative potential of adipose derived stem cells [J].

Duscher, Dominik ;

Luan, Anna ;

Rennert, Robert C. ;

Atashroo, David ;

Maan, Zeshaan N. ;

Brett, Elizabeth A. ;

Whittam, Alexander J. ;

Ho, Natalie ;

Lin, Michelle ;

Hu, Michael S. ;

Walmsley, Graham G. ;

Wenny, Raphael ;

Schmidt, Manfred ;

Schilling, Arndt F. ;

Machens, Hans-Guenther ;

Huemer, Georg M. ;

Wan, Derrick C. ;

Longaker, Michael T. ;

Gurtner, Geoffrey C. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2016, 14

[16] Ultrasound-Assisted Liposuction Does Not Compromise the Regenerative Potential of Adipose-Derived Stem Cells [J].

Duscher, Dominik ;

Atashroo, David ;

Maan, Zeshaan N. ;

Luan, Anna ;

Brett, Elizabeth A. ;

Barrera, Janos ;

Khong, Sacha M. ;

Zielins, Elizabeth R. ;

Whittam, Alexander J. ;

Hu, Michael S. ;

Walmsley, Graham G. ;

Pollhammer, Michael S. ;

Schmidt, Manfred ;

Schilling, Arndt F. ;

Machens, Hans-Guenther ;

Huemer, Georg M. ;

Wan, Derrick C. ;

Longaker, Michael T. ;

Gurtner, Geoffrey C. .

STEM CELLS TRANSLATIONAL MEDICINE, 2016, 5 (02) :248-257

[17] Molecular mechanism of hypoxia-induced chondrogenesis and its application in in vivo cartilage tissue engineering [J].

Duval, Elise ;

Bauge, Catherine ;

Andriamanalijaona, Rina ;

Benateau, Herve ;

Leclercq, Sylvain ;

Dutoit, Soizic ;

Poulain, Laurent ;

Galera, Philippe ;

Boumediene, Karim .

BIOMATERIALS, 2012, 33 (26) :6042-6051

[18] Fibroblast-Derived Extracellular Matrix Induces Chondrogenic Differentiation in Human Adipose-Derived Mesenchymal Stromal/Stem Cells in Vitro [J].

Dzobo, Kevin ;

Turnley, Taegyn ;

Wishart, Andrew ;

Rowe, Arielle ;

Kallmeyer, Karlien ;

van Vollenstee, Fiona A. ;

Thomford, Nicholas E. ;

Dandara, Collet ;

Chopera, Denis ;

Pepper, Michael S. ;

Parker, M. Iqbal .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (08)

[19] The Effect of Hypoxia on Mesenchymal Stem Cell Biology [J].

Ejtehadifar, Mostafa ;

Shamsasenjan, Karim ;

Movassaghpour, Aliakbar ;

Akbarzadehlaleh, Parvin ;

Dehdilani, Nima ;

Abbasi, Parvaneh ;

Molaeipour, Zahra ;

Saleh, Mahshid .

ADVANCED PHARMACEUTICAL BULLETIN, 2015, 5 (02) :141-149

[20] Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation [J].

Eljaafari, Assia ;

Robert, Maud ;

Chehimi, Marwa ;

Chanon, Stephanie ;

Durand, Christine ;

Vial, Guillaume ;

Bendridi, Nadia ;

Madec, Anne-Marie ;

Disse, Emmanuel ;

Laville, Martine ;

Rieusset, Jennifer ;

Lefai, Etienne ;

Vidal, Hubert ;

Pirola, Luciano .

DIABETES, 2015, 64 (07) :2477-2488

← 1 2 3 4 5 6 7 8 9 →