Effect of hypoxia on human adipose-derived mesenchymal stem cells and its potential clinical applications

被引：65
作者：
Choi, Jane Ru [1 ]
Yong, Kar Wey [1 ]
Safwani, Wan Kamarul Zaman Wan [1 ]
机构：
[1] Univ Malaya, Dept Biomed Engn, Fac Engn, Kuala Lumpur 50603, Malaysia
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2017年 / 74卷 / 14期
关键词：
Hypoxia; hASCs; Phenotype; Functionality; Clinical applications; Challenges; LOW-OXYGEN TENSION; CHONDROGENIC DIFFERENTIATION; ENDOTHELIAL-CELLS; STROMAL CELLS; EXPRESSION; SECRETION; SURVIVAL; GROWTH; PROLIFERATION; HIF-1-ALPHA;
D O I：
10.1007/s00018-017-2484-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Human adipose-derived mesenchymal stem cells (hASCs) are an ideal cell source for regenerative medicine due to their capabilities of multipotency and the readily accessibility of adipose tissue. They have been found residing in a relatively low oxygen tension microenvironment in the body, but the physiological condition has been overlooked in most studies. In light of the escalating need for culturing hASCs under their physiological condition, this review summarizes the most recent advances in the hypoxia effect on hASCs. We first highlight the advantages of using hASCs in regenerative medicine and discuss the influence of hypoxia on the phenotype and functionality of hASCs in terms of viability, stemness, proliferation, differentiation, soluble factor secretion, and biosafety. We provide a glimpse of the possible cellular mechanism that involved under hypoxia and discuss the potential clinical applications. We then highlight the existing challenges and discuss the future perspective on the use of hypoxic-treated hASCs.
引用
收藏
页码：2587 / 2600
页数：14
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