Reward-related neural activity and structure predict future substance use in dysregulated youth

被引:18
作者
Bertocci, M. A. [1 ]
Bebko, G. [1 ]
Versace, A. [1 ]
Iyengar, S. [2 ]
Bonar, L. [1 ]
Forbes, E. E. [1 ]
Almeida, J. R. C. [1 ]
Perlman, S. B. [1 ]
Schirda, C. [1 ]
Travis, M. J. [1 ]
Gill, M. K. [1 ]
Diwadkar, V. A. [3 ]
Sunshine, J. L. [4 ]
Holland, S. K. [5 ]
Kowatch, R. A. [6 ]
Birmaher, B. [1 ]
Axelson, D. A. [6 ]
Frazier, T. W. [7 ]
Arnold, L. E. [6 ]
Fristad, M. A. [6 ]
Youngstrom, E. A. [8 ]
Horwitz, S. M. [9 ]
Findling, R. L. [10 ]
Phillips, M. L. [1 ]
机构
[1] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Med Ctr, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Stat, Pittsburgh, PA USA
[3] Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI 48207 USA
[4] Case Western Reserve Univ, Dept Radiol, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA
[5] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA
[6] Ohio State Univ, Dept Psychiat & Behav Hlth, Columbus, OH 43210 USA
[7] Cleveland Clin, Inst Pediat, Cleveland, OH 44106 USA
[8] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA
[9] NYU, Sch Med, Dept Child & Adolescent Psychiat, New York, NY USA
[10] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD USA
关键词
Functional magnetic resonance imaging; GLMNET; LASSO; substance use; youth; FUNCTIONAL CONNECTIVITY; LONGITUDINAL ASSESSMENT; ALCOHOL-USE; AFFECTIVE-DISORDERS; CEREBRAL ASYMMETRY; CIRCUITRY FUNCTION; TREATMENT RESPONSE; BIPOLAR DISORDER; ADOLESCENTS; CHILDREN;
D O I
10.1017/S0033291716003147
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background. Identifying youth who may engage in future substance use could facilitate early identification of substance use disorder vulnerability. We aimed to identify biomarkers that predicted future substance use in psychiatrically un-well youth. Method. LASSO regression for variable selection was used to predict substance use 24.3 months after neuroimaging assessment in 73 behaviorally and emotionally dysregulated youth aged 13.9 (s.d. = 2.0) years, 30 female, from three clinical sites in the Longitudinal Assessment of Manic Symptoms (LAMS) study. Predictor variables included neural activity during a reward task, cortical thickness, and clinical and demographic variables. Results. Future substance use was associated with higher left middle prefrontal cortex activity, lower left ventral anterior insula activity, thicker caudal anterior cingulate cortex, higher depression and lower mania scores, not using antipsychotic medication, more parental stress, older age. This combination of variables explained 60.4% of the variance in future substance use, and accurately classified 83.6%. Conclusions. These variables explained a large proportion of the variance, were useful classifiers of future substance use, and showed the value of combining multiple domains to provide a comprehensive understanding of substance use development. This may be a step toward identifying neural measures that can identify future substance use disorder risk, and act as targets for therapeutic interventions.
引用
收藏
页码:1357 / 1369
页数:13
相关论文
共 70 条
[31]   Longitudinal Assessment of Manic Symptoms (LAMS) Study: Background, Design, and Initial Screening Results [J].
Horwitz, Sarah McCue ;
Demeter, Christine A. ;
Pagano, Maria E. ;
Youngstrom, Eric A. ;
Fristad, Mary A. ;
Arnold, L. Eugene ;
Birmaher, Boris ;
Gill, Mary Kay ;
Axelson, David ;
Kowatch, Robert A. ;
Frazier, Thomas W. ;
Findling, Robert L. .
JOURNAL OF CLINICAL PSYCHIATRY, 2010, 71 (11) :1511-1517
[32]   Neurophysiological Markers That Predict and Track Treatment Outcomes in Childhood Anxiety [J].
Hum, Kathryn M. ;
Manassis, Katharina ;
Lewis, Marc D. .
JOURNAL OF ABNORMAL CHILD PSYCHOLOGY, 2013, 41 (08) :1243-1255
[33]   PATTERNS OF DRUG-USE FROM ADOLESCENCE TO YOUNG ADULTHOOD .1. PERIODS OF RISK FOR INITIATION, CONTINUED USE, AND DISCONTINUATION [J].
KANDEL, DB ;
LOGAN, JA .
AMERICAN JOURNAL OF PUBLIC HEALTH, 1984, 74 (07) :660-666
[34]   Schedule for Affective Disorders and Schizophrenia for School-Age Children Present and Lifetime version (K-SADS-PL): Initial reliability and validity data [J].
Kaufman, J ;
Birmaher, B ;
Brent, D ;
Rao, U ;
Flynn, C ;
Moreci, P ;
Williamson, D ;
Ryan, N .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1997, 36 (07) :980-988
[35]   Discovery and replication of gene influences on brain structure using LASSO regression [J].
Kohannim, Omid ;
Hibar, Derrek P. ;
Stein, Jason L. ;
Jahanshad, Neda ;
Hua, Xue ;
Rajagopalan, Priya ;
Toga, Arthur W. ;
Jack, Clifford R., Jr. ;
Weiner, Michael W. ;
de Zubicaray, Greig I. ;
McMahon, Katie L. ;
Hansell, Narelle K. ;
Martin, Nicholas G. ;
Wright, Margaret J. ;
Thompson, Paul M. .
FRONTIERS IN NEUROSCIENCE, 2012, 6
[36]  
Kohannim O, 2012, 2012 9TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI), P1160, DOI 10.1109/ISBI.2012.6235766
[37]   Psychosocial correlates of substance use in adolescence: A cross-national study in six European countries [J].
Kokkevi, Anna ;
Richardson, Clive ;
Florescu, Silvia ;
Kuzman, Marina ;
Stergar, Eva .
DRUG AND ALCOHOL DEPENDENCE, 2007, 86 (01) :67-74
[38]   Further investigation of psychological and environmental correlates of substance use in adolescence in six European countries [J].
Kokkevi, Anna E. ;
Arapaki, Angeliki A. ;
Richardson, Clive ;
Florescu, Silvia ;
Kuzman, Marina ;
Stergar, Eva .
DRUG AND ALCOHOL DEPENDENCE, 2007, 88 (2-3) :308-312
[39]   The neural basis of financial risk taking [J].
Kuhnen, CM ;
Knutson, B .
NEURON, 2005, 47 (05) :763-770
[40]   The Child and Adolescent Symptom Inventory-Progress Monitor: A Brief Diagnostic and Statistical Manual of Mental Disorders, 4th Edition-Referenced Parent-Report Scale for Children and Adolescents [J].
Lavigne, John V. ;
Cromley, Taya ;
Sprafkin, Joyce ;
Gadow, Kenneth D. .
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 2009, 19 (03) :241-252