Magnetic calcium phosphates nanocomposites for the intracellular hyperthermia of cancers of bone and brain

被引：41

作者：

Adamiano, Alessio ^{[1
]}

Wu, Victoria M. ^{[2
]}

Carella, Francesca ^{[1
]}

Lamura, Gianrico ^{[3
]}

Canepa, Fabio ^{[3
,4
]}

Tampieri, Anna ^{[1
]}

Iafisco, Michele ^{[1
]}

Uskokovic, Vuk ^{[2
,5
]}

机构：

[1] Natl Res Council CNR, Inst Sci & Technol Ceram ISTEC, Via Granarolo 64, I-48018 Faenza, Italy

[2] Chapman Univ, Ctr Targeted Drug Delivery, Dept Biomed & Pharmaceut Sci, Irvine, CA 92618 USA

[3] Natl Res Council CNR, Inst Superconductors Oxides & Other Innovat Mat &, Corso Perrone 24, I-16152 Genoa, Italy

[4] Univ Genoa, Dept Chem & Ind Chem, Via Dodecaneso 31, I-16146 Genoa, Italy

[5] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA

来源：

NANOMEDICINE | 2019年 / 14卷 / 10期

基金：

欧盟地平线“2020”;

关键词：

calcium phosphate; composite nanoparticles; glioblastoma; magnetic hyperthermia; nanoparticles; osteosarcoma; IRON-OXIDE NANOPARTICLES; HYDROXYAPATITE; THERAPY; PARTICLES;

D O I：

10.2217/nnm-2018-0372

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Magnetic hyperthermia is limited by the low selective susceptibility of neoplastic cells interspersed within healthy tissues, which we aim to improve on. Materials & methods: Two superparamagnetic calcium phosphates nanocomposites, that is, iron-doped hydroxyapatite and iron oxide (Mag) nanoparticles coated with amorphous calcium phosphate (Mag@CaP), were synthesized and tested for selective activity against brain and bone cancers. Results: Nanoparticle uptake and intracellular localization were prerequisites for reduction of cancer viability in alternate magnetic fields of extremely low power. Sheer adsorption onto the outer membrane was not sufficient to produce this effect, which was extremely significant for Mag@CaP and iron-doped hydroxyapatite, but negligible for Mag, demonstrating benefits of combining magnetic iron with calcium phosphates. Conclusion: Such selective effects are important in the global effort to rejuvenate clinical prospects of magnetic hyperthermia.

引用

页码：1267 / 1289

页数：23

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