FOXM1 and Cancer: Faulty Cellular Signaling Derails Homeostasis

被引：116

作者：

Kalathil, Dhanya ^{[1
]}

John, Samu ^{[1
,2
]}

Nair, Asha S. ^{[1
,2
]}

机构：

[1] Rajiv Gandhi Ctr Biotechnol, Canc Res Program 4, Thiruvananthapuram, Kerala, India

[2] Univ Kerala, Res Ctr, Thiruvananthapuram, Kerala, India

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 10卷

关键词：

FOXM1; cell signaling; post-transcriptional regulation; post-translational regulation; miRNA; FORKHEAD BOX M1; HEPATOCELLULAR-CARCINOMA; TARGETING FOXM1; MESENCHYMAL TRANSITION; DOWNSTREAM TARGET; PANCREATIC-CANCER; EXPRESSION; PROGRESSION; PROLIFERATION; GENE;

D O I：

10.3389/fonc.2020.626836

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Forkhead box transcription factor, FOXM1 is implicated in several cellular processes such as proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue homeostasis, angiogenesis, apoptosis, and redox signaling. In addition to being a boon for the normal functioning of a cell, FOXM1 turns out to be a bane by manifesting in several disease scenarios including cancer. It has been given an oncogenic status based on several evidences indicating its role in tumor development and progression. FOXM1 is highly expressed in several cancers and has also been implicated in poor prognosis. A comprehensive understanding of various aspects of this molecule has revealed its role in angiogenesis, invasion, migration, self- renewal and drug resistance. In this review, we attempt to understand various mechanisms underlying FOXM1 gene and protein regulation in cancer including the different signaling pathways, post-transcriptional and post-translational modifications. Identifying crucial molecules associated with these processes can aid in the development of potential pharmacological approaches to curb FOXM1 mediated tumorigenesis.

引用

页数：23

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