The prevalence of sacroiliitis in patients with acne vulgaris using isotretinoin

被引:21
作者
Selcuk, Leyla Baykal [1 ]
Arica, Deniz Aksu [1 ]
Sahin, Hanife Baykal [2 ]
Yayli, Savas [1 ]
Bahadir, Sevgi [1 ]
机构
[1] Karadeniz Tech Univ, Sch Med, Dermatol Dept, Trabzon, Turkey
[2] Macka Omer Burhanoglu Phys Therapy & Rehabil Hosp, Phys Therapy & Rehabil Dept, Trabzon, Turkey
关键词
Acne vulgaris; isotretinoin; low back; pain; sacroiliitis; ORAL ISOTRETINOIN; SPONDYLOARTHRITIS; SYMPTOMS; CRITERIA;
D O I
10.1080/15569527.2016.1237521
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Background/Objective: Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit in the skin. Isotretinoin is a synthetic vitamin A derivative regarded as the most effective agent in the treatment of acne. There have recently been increasing reports of adverse effects of isotretinoin on the skeletal system. Our aim in this study was to evaluate the rheumatic side-effects triggered by this drug, and particularly the prevalence of sacroiliitis.Materials and methods: A total of 73 patients receiving isotretinoin due to moderate or severe acne vulgaris were included. All patients were questioned about inflammatory low back pain and musculoskeletal pains during the treatment process. Inflammatory low back pain was evaluated using Assessment of Spondyloarthritis International Society (ASAS) criteria. Patients meeting ASAS criteria were evaluated with radiography and when necessary with sacroiliac magnetic resonance.Results: The dose range for isotretinoin was between 0.4 and 0.8mg/kg/day (mean 0.53mg/kg/day). Treatment lasted for 6-8 months (mean 6.8 months). Lethargy was determined in 37 (50.7%) patients, myalgia in 31 (42.5%) and low back pain in 36 (49.3%). Mechanical low back pain symptoms were present in 20 of the patients describing low back pain and inflammatory low back pain in 16. Acute sacroiliitis was determined in six patients (8.2%) following a sacroiliac magnetic resonance imaging (MRI). Five (83.3%) of the patients with sacroiliitis were female and one (16.7%) was male. No statistically significant difference was determined between male and female patients in terms of prevalence of sacroiliitis (p =0.392).Conclusion: The incidence of sacroiliitis in patients using isotretinoin is quite high. Patients using isotretinoin must be questioned about sacroiliitis findings and must be subjected to advanced assessment when necessary. Further studies regarding the development of sacroiliitis under isotretinoin therapy are now needed.
引用
收藏
页码:176 / 179
页数:4
相关论文
共 21 条
[1]   Isotretinoin-induced Spondyloarthropathy-related Symptoms: A Prospective Study [J].
Alkan, Samet ;
Kayiran, Nuriye ;
Zengin, Orhan ;
Kalem, Ali ;
Kimyon, Gezmis ;
Kilinc, Emine Ozkul ;
Pehlivan, Yavuz ;
Kirtak, Necmettin ;
Onat, Ahmet Mesut ;
Kisacik, Bunyamin .
JOURNAL OF RHEUMATOLOGY, 2015, 42 (11) :2106-2109
[2]   Unilateral sacroiliitis associated with systemic isotretinoin treatment [J].
Barbareschi, Mauro ;
Paresce, Erberto ;
Chiaratti, Anna ;
Lodigiani, Alessandra Ferla ;
Clerici, Giovanna ;
Greppi, Franco .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2010, 49 (03) :331-333
[3]   Sacroiliitis after use of oral isotretinoin - association with acne fulminans or adverse effect? [J].
Bastos Geller, Ariane Silva ;
Nazareth Alagia, Roberta Ferreira .
ANAIS BRASILEIROS DE DERMATOLOGIA, 2013, 88 (06) :193-196
[4]   Matrix metalloproteinases: Role in arthritis [J].
Burrage, PS ;
Mix, KS ;
Brinckerhoff, CE .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2006, 11 :529-543
[5]  
Dinçer Ü, 2008, ROMATIZMA, V23, P157
[6]   Sacroiliitis and polyneuropathy during isotretinoin treatment [J].
Eksioglu, E. ;
Oztekin, F. ;
Unlu, E. ;
Cakci, A. ;
Keyik, B. ;
Karadavut, I. K. .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2008, 33 (02) :122-124
[7]   From new findings in acne pathogenesis to new approaches in treatment [J].
Gollnick, H. P. M. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2015, 29 :1-7
[8]   Predisposition for spinal fracture in ankylosing spondylitis [J].
Hanson, JA ;
Mirza, S .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2000, 174 (01) :150-150
[9]   RHEUMATOLOGICAL SYMPTOMS DUE TO RETINOIDS [J].
KAPLAN, G ;
HAETTICH, B .
BAILLIERES CLINICAL RHEUMATOLOGY, 1991, 5 (01) :77-97
[10]  
Kircik LH, 2016, J DRUGS DERMATOL, V15, pS76