Suppressors of cytokine signalling (SOCS) in the immune system

被引：549

作者：

Alexander, WS ^{[1
]}

机构：

[1] PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

[2] PO Royal Melbourne Hosp, Cooperat Res Ctr Cellular Growth Factors, Melbourne, Vic 3050, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 06期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1038/nri818

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The suppressors of cytokine signalling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the immune system, The SOCS proteins seem to regulate signal transduction by combining direct inhibitory interactions with cytokine receptors and signalling proteins with a generic mechanism of targeting associated proteins for degradation. Evidence is emerging for the involvement of SOCS proteins in diseases of the human immune system, which raises the possibility that therapeutic strategies that are based on the manipulation of SOCS activity might be of clinical benefit.

引用

页码：410 / 416

页数：7

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