Does edaravone (MCI-186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?

被引：29

作者：

Dohi, Kenji

Satoh, Kazue

Nakamachi, Tomoya

Yofu, Sachiko

Hiratsuka, Keisuke

Nakamura, Shunsuke

Ohtaki, Hirokazu

Yoshikawa, Toshikazu

Shioda, Seiji

Aruga, Tohru

机构：

[1] Showa Univ, Sch Med, Dept Emergency & Crit Care Med, Shinagawa Ku, Tokyo 1428555, Japan

[2] Showa Univ, Dept Anat, Tokyo 1428555, Japan

[3] Kyoto Prefectural Univ Med, Dept Med 1, Kyoto, Japan

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2007年 / 9卷 / 02期

关键词：

D O I：

10.1089/ars.2007.9.281

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.

引用

页码：281 / 287

页数：7

共 30 条

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