A First-Generation Haplotype Map of Maize

被引：559

作者：

Gore, Michael A. ^{[1
,2
,3
]}

Chia, Jer-Ming ^{[4
]}

Elshire, Robert J. ^{[3
]}

Sun, Qi ^{[5
]}

Ersoz, Elhan S. ^{[3
]}

Hurwitz, Bonnie L. ^{[4
]}

Peiffer, Jason A. ^{[2
]}

McMullen, Michael D. ^{[1
,6
]}

Grills, George S. ^{[7
]}

Ross-Ibarra, Jeffrey ^{[8
]}

Ware, Doreen H. ^{[1
,4
]}

Buckler, Edward S. ^{[1
,2
,3
]}

机构：

[1] Cornell Univ, USDA ARS, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Genet & Plant Breeding, Ithaca, NY 14853 USA

[3] Cornell Univ, Inst Genom Divers, Ithaca, NY 14853 USA

[4] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[5] Cornell Univ, Computat Biol Serv Unit, Ithaca, NY 14853 USA

[6] Univ Missouri, Div Plant Sci, Columbia, MO 65211 USA

[7] Cornell Univ, Inst Biotechnol & Life Sci Technol, Ithaca, NY 14853 USA

[8] Univ Calif Davis, Dept Plant Sci, Davis, CA 95616 USA

来源：

SCIENCE | 2009年 / 326卷 / 5956期

基金：

美国国家科学基金会;

关键词：

ARTIFICIAL SELECTION; ARABIDOPSIS-THALIANA; GENOME; POPULATION; DOMESTICATION; DIVERSITY; DNA; POLYMORPHISM; DIVERGENCE; ZEA;

D O I：

10.1126/science.1177837

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Maize is an important crop species of high genetic diversity. We identified and genotyped several million sequence polymorphisms among 27 diverse maize inbred lines and discovered that the genome was characterized by highly divergent haplotypes and showed 10- to 30-fold variation in recombination rates. Most chromosomes have pericentromeric regions with highly suppressed recombination that appear to have influenced the effectiveness of selection during maize inbred development and may be a major component of heterosis. We found hundreds of selective sweeps and highly differentiated regions that probably contain loci that are key to geographic adaptation. This survey of genetic diversity provides a foundation for uniting breeding efforts across the world and for dissecting complex traits through genome-wide association studies.

引用

页码：1115 / 1117

页数：3

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