An in vitro and in silico evaluation of bioactive potential of cornelian cherry (Cornus mas L.) extracts rich in polyphenols and iridoids

被引：44

作者：

Blagojevic, Bojana ^{[1
]}

Agic, Dejan ^{[2
]}

Serra, Ana Teresa ^{[3
,4
]}

Matic, Sara ^{[5
]}

Matovina, Mihaela ^{[5
]}

Bijelic, Sandra ^{[6
]}

Popovic, Boris M. ^{[1
]}

机构：

[1] Univ Novi Sad, Fac Agr, Dept Field & Vegetable Crops, Trg Dositeja Obradovica 8, Novi Sad 21000, Serbia

[2] Josip Juraj Strossmayer Univ Osijek, Fac Agrobiotech Sci Osijek, Vladimira Preloga 1, Osijek 31000, Croatia

[3] Univ Nova Lisboa ITQB NOVA, Inst Tecnol Quim & Biol Antonio Xavier, Oeiras, Portugal

[4] Inst Biol Expt & Tecnol, IBET, Apartado 12, Oeiras, Portugal

[5] Rudjer Boskovic Inst, Div Organ Chem & Biochem, Bijenicka 54, Zagreb 10000, Croatia

[6] Univ Novi Sad, Fac Agr, Dept Fruit Growing Viticulture Hort & Landscape A, Trg Dositeja Obradovica 8, Novi Sad 21000, Serbia

来源：

FOOD CHEMISTRY | 2021年 / 335卷

关键词：

Cornelian cherry; Cornus mas; Antioxidants; HT29; alpha-Amylase; alpha-Glucosidase; Dipeptidyl peptidase III; DIPEPTIDYL PEPTIDASE-III; ANTIOXIDANT CAPACITY; PHENOLIC-COMPOUNDS; ALPHA-AMYLASE; FLAVONOIDS; FRUITS; ACID; ANTHOCYANINS; INHIBITION; GENOTYPES;

D O I：

10.1016/j.foodchem.2020.127619

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In the present research, seven different cornelian cherry (Cornus mas L.) cultivars and selections were examined. In vitro and in silico methods were applied for determining and correlating phytochemical constituents and biological potential. Loganic acid, cornuside, cyanidin 3-galactoside, and pelargonidin 3-galactoside were determined as the most dominant compounds, presenting >= 90% of the all detected iridoid and phenolic constituents in the extracts. Cornelian cherry fruits were characterized by high antioxidant capacity and anti-proliferative activity on human colon cancer cells (HT29). It was observed the strong inhibitory potential of alpha-amylase, alpha-glucosidase, and dipeptidyl peptidase III (DPP III) enzyme activities. Principal component analysis (PCA) was used as a very helpful tool to discriminate the constituents with the highest contribution to tested bioactivities and to highlight the most potent genotypes. PCA, together with binding energies measurements and docking analysis, pointed out pelargonidin 3-robinobioside as the strongest inhibitor of alpha-glucosidase.

引用

页数：8

共 41 条

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