The effect of erythrodiol-3-acetate on the expressions of matrix metalloproteinase-1 and type-1 procollagen caused by ultraviolet irradiated cultured primary old aged human skin fibroblasts

被引：12

作者：

Moon, H. -I. ^{[1
]}

Lee, J.

Chung, J. H.

机构：

[1] Univ Kentucky, Med Ctr, Dept Surg, Mol Neurosci & Vasc Biol Lab, Lexington, KY 40536 USA

[2] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Dermatol, Seoul 110744, South Korea

[4] Seoul Natl Univ, Inst Dematol Sci, Seoul 110744, South Korea

来源：

PHYTOMEDICINE | 2006年 / 13卷 / 9-10期

关键词：

erythrodiol-3-acetate; matrix metalloproteinase-1; type-1; procollagen; ultra violet;

D O I：

10.1016/j.phymed.2005.10.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Methanol and aqueous extracts of Styrax japonica used traditionally for the treatments of skin elastic materials were screened in vitro for the matrix metalloproteinase (MMP)-1 inhibitor actions. The methylene chloride soluble fraction of methanol extract from the stems of S. japonica showed significant MMP-1 inhibition in primary old aged human skin fibroblasts caused by ultraviolet (UV) irradiation. Main triterpenoids were isolated by repeated column chromatography. Among them, the triterpenoid erythrodiol-3-acetate reduced the expression of MMP-1 and induced the expression of type-1 procollagen at the protein levels in a dose-dependent manner caused by UV irradiated cultured old aged human skin fibroblasts. Taken together, our results suggest that erythrodiol-3-acetate plays an important role in the skin aging process caused by UV irradiation. (c) 2005 Elsevier GmbH. All rights reserved.

引用

页码：707 / 711

页数：5

共 16 条

[1] Benzofurans and another constituent from seeds of Styrax officinalis [J].

Akgul, YY ;

Anil, H .

PHYTOCHEMISTRY, 2003, 63 (08) :939-943

[2] 4 BENZOFURAN GLYCOSIDES FROM STYRAX-OFFICINALIS [J].

ANIL, H .

PHYTOCHEMISTRY, 1980, 19 (12) :2784-2786

[3]

Costa A. F., 1968, FARMACOGNOSIA, V1, P737

[4] Molecular basis of sun-induced premature skin ageing and retinoid antagonism [J].

Fisher, GJ ;

Datta, SC ;

Talwar, HS ;

Wang, ZQ ;

Varani, J ;

Kang, S ;

Voorhees, JJ .

NATURE, 1996, 379 (6563) :335-339

[5] Pentacyclic triterpenoids and their cytotoxicity from the stem bark of Styrax japonica S. et Z. [J].

Kim, MR ;

Lee, HH ;

Hahm, KS ;

Moon, YH ;

Woo, ER .

ARCHIVES OF PHARMACAL RESEARCH, 2004, 27 (03) :283-286

[6] TRITERPENES IN ORGAN PIPE CACTUS [J].

KIRCHER, HW .

PHYTOCHEMISTRY, 1980, 19 (12) :2707-2712

[7]

KITAGAWA I, 1975, CHEM PHARM BULL, V23, P1520

[8]

Lee T.B., 1982, Illustrated Flora of Korea, P614

[9] New furofuran and butyrolactone lignans with antioxidant activity from the stem bark of Styrax japonica [J].

Min, LS ;

Na, MK ;

Oh, SR ;

Ahn, KS ;

Jeong, GS ;

Li, G ;

Lee, SK ;

Joung, H ;

Lee, HK .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (12) :1980-1984

[10] RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].

MOSMANN, T .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63

← 1 2 →