Deregulated degradation of the cdk inhibitor p27 and malignant transformation

被引：324
作者：
Bloom, J
Pagano, M
机构：
[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA
[2] NYU, Sch Med, Inst Canc, New York, NY 10016 USA
来源：
SEMINARS IN CANCER BIOLOGY | 2003年 / 13卷 / 01期
关键词：
cancer; cell cycled; ubiquitin; proteolysis; F-box proteins; SCF ubiquitin-ligases; Skp2; p27;
D O I：
10.1016/S1044-579X(02)00098-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
p27 acts as a critical negative regulator of the cell cycle by inhibiting the activity of cyclin/cdk complexes during G0 and G1. Degradation of p27 is a critical event for the G1/S transition and occurs through ubiquitination by SCFSkp2 and subsequent degradation by the 26S-proteasome. A tumor suppressing function of p27 has been demonstrated in mouse models and studies of human tumors. More recent evidence suggests that Skp2, the specific recognition factor for p27 ubiquitination, has oncogenic properties. This review will focus on the regulation of p27 proteolysis and its consequences for tumorigenesis. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：41 / 47
页数：7
相关论文
共 73 条
[1]   Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells [J].
Baldassarre, G ;
Belletti, B ;
Bruni, P ;
Boccia, A ;
Trapasso, F ;
Pentimalli, F ;
Barone, MV ;
Chiappetta, G ;
Vento, MT ;
Spiezia, S ;
Fusco, A ;
Viglietto, G .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (07) :865-874
[2]   p27 destruction: Cks1 pulls the trigger [J].
Bartek, J ;
Lukas, J .
NATURE CELL BIOLOGY, 2001, 3 (04) :E95-E98
[3]   A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression [J].
Boehm, M ;
Yoshimoto, T ;
Crook, MF ;
Nallamshetty, S ;
True, A ;
Nabel, GJ ;
Nabel, EG .
EMBO JOURNAL, 2002, 21 (13) :3390-3401
[4]   SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 [J].
Carrano, AC ;
Eytan, E ;
Hershko, A ;
Pagano, M .
NATURE CELL BIOLOGY, 1999, 1 (04) :193-199
[5]   Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression [J].
Carrano, AC ;
Pagano, M .
JOURNAL OF CELL BIOLOGY, 2001, 153 (07) :1381-1389
[6]   Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma [J].
Chiarle, R ;
Budel, LM ;
Skolnik, J ;
Frizzera, G ;
Chilosi, M ;
Corato, A ;
Pizzolo, G ;
Magidson, J ;
Montagnoli, A ;
Pagano, M ;
Maes, B ;
De Wolf-Peeters, C ;
Inghirami, G .
BLOOD, 2000, 95 (02) :619-626
[7]   S-Phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase [J].
Chiarle, R ;
Fan, Y ;
Piva, R ;
Boggino, H ;
Skolnik, J ;
Novero, D ;
Palestro, G ;
De Wolf-Peeters, C ;
Chilosi, M ;
Pagano, M ;
Inghirami, G .
AMERICAN JOURNAL OF PATHOLOGY, 2002, 160 (04) :1457-1466
[8]  
Ciaparrone M, 1998, CANCER RES, V58, P114
[9]   Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumours [J].
Dahia, PLM ;
Aguiar, RCT ;
Honegger, J ;
Fahlbush, R ;
Jordan, S ;
Lowe, DG ;
Lu, X ;
Clayton, R ;
Besser, GM ;
Grossman, AB .
ONCOGENE, 1998, 16 (01) :69-76
[10]   CRYSTAL-STRUCTURE OF CYCLIN-DEPENDENT KINASE-2 [J].
DEBONDT, HL ;
ROSENBLATT, J ;
JANCARIK, J ;
JONES, HD ;
MORGAN, DO ;
KIM, SH .
NATURE, 1993, 363 (6430) :595-602
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