Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock

被引：12

作者：

Belsky, Justin B. ^{[1
]}

Morris, Daniel C. ^{[2
]}

Bouchebl, Ralph ^{[3
]}

Filbin, Michael R. ^{[1
]}

Bobbitt, Kevin R. ^{[4
]}

Jaehne, Anja K. ^{[2
,5
]}

Rivers, Emanuel P. ^{[2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Emergency Med, 55 Fruit St,Zero Emerson Pl,Suite 3B, Boston, MA 02114 USA

[2] Henry Ford Hosp, Dept Emergency Med, Detroit, MI 48202 USA

[3] Amer Univ Beirut, Dept Emergency Med, Beirut, Lebanon

[4] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA

[5] Northstar Hlth Syst, Dept Qual, Iron River, MI USA

来源：

BIOMARKERS | 2016年 / 21卷 / 02期

关键词：

thymosin beta 4; F-actin; Actin; actin binding protein; G-actin; septic shock; coronary artery bypass graft; SEVERE SEPSIS; INFLAMMATORY RESPONSE; GELSOLIN; RESUSCITATION; MORTALITY; THERAPY;

D O I：

10.3109/1354750X.2015.1126646

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: To compare plasma levels of F-actin, G-actin and thymosin beta 4 (TB4) in humans with septic shock, noninfectious systemic inflammatory response syndrome (SIRS) and healthy controls. Results: F-actin was significantly elevated in septic shock as compared with noninfectious SIRS and healthy controls. G-actin levels were greatest in the noninfectious SIRS group but significantly elevated in septic shock as compared with healthy controls. TB4 was not detectable in the septic shock or noninfectious SIRS group above the assay's lowest detection range (78 ng/ml). Conclusions: F-actin is significantly elevated in patients with septic shock as compared with noninfectious SIRS. F-actin and the F:G-actin ratio are potential biomarkers for the diagnosis of septic shock.

引用

页码：180 / 185

页数：6

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