Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock

被引：12

作者：

Belsky, Justin B. ^{[1
]}

Morris, Daniel C. ^{[2
]}

Bouchebl, Ralph ^{[3
]}

Filbin, Michael R. ^{[1
]}

Bobbitt, Kevin R. ^{[4
]}

Jaehne, Anja K. ^{[2
,5
]}

Rivers, Emanuel P. ^{[2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Emergency Med, 55 Fruit St,Zero Emerson Pl,Suite 3B, Boston, MA 02114 USA

[2] Henry Ford Hosp, Dept Emergency Med, Detroit, MI 48202 USA

[3] Amer Univ Beirut, Dept Emergency Med, Beirut, Lebanon

[4] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA

[5] Northstar Hlth Syst, Dept Qual, Iron River, MI USA

来源：

BIOMARKERS | 2016年 / 21卷 / 02期

关键词：

thymosin beta 4; F-actin; Actin; actin binding protein; G-actin; septic shock; coronary artery bypass graft; SEVERE SEPSIS; INFLAMMATORY RESPONSE; GELSOLIN; RESUSCITATION; MORTALITY; THERAPY;

D O I：

10.3109/1354750X.2015.1126646

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Objective: To compare plasma levels of F-actin, G-actin and thymosin beta 4 (TB4) in humans with septic shock, noninfectious systemic inflammatory response syndrome (SIRS) and healthy controls. Results: F-actin was significantly elevated in septic shock as compared with noninfectious SIRS and healthy controls. G-actin levels were greatest in the noninfectious SIRS group but significantly elevated in septic shock as compared with healthy controls. TB4 was not detectable in the septic shock or noninfectious SIRS group above the assay's lowest detection range (78 ng/ml). Conclusions: F-actin is significantly elevated in patients with septic shock as compared with noninfectious SIRS. F-actin and the F:G-actin ratio are potential biomarkers for the diagnosis of septic shock.

引用

页码：180 / 185

页数：6

共 49 条

[1] EFFECT OF PHALLOIDIN ON THE STABILITY OF F-ACTIN AND G-ACTIN
VEDENKINA, NS
KALINICHENKO, LP
PERMYAKOV, EA
MOLECULAR BIOLOGY, 1995, 29 (03) : 349 - 352
[2] FT-Raman studies on the transformation of G-actin to F-actin, the binding of cisplatin and transplatin to F-actin and the effects of the conformation of F-actin
Zeng, HH
Xu, ZH
Wang, K
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1997, 20 (02) : 107 - 113
[3] Calponin binds G-actin and F-actin with similar affinity
Ferjani, Imen
Fattoum, Abdellatif
Maciver, Sutherland K.
Manai, Mohamed
Benyamin, Yves
Roustan, Claude
FEBS LETTERS, 2006, 580 (20) : 4801 - 4806
[4] SIMULTANEOUS VISUALIZATION OF G-ACTIN AND F-ACTIN IN ENDOTHELIAL-CELLS
HAUGLAND, RP
YOU, WM
PARAGAS, VB
WELLS, KS
DUBOSE, DA
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1994, 42 (03) : 345 - 350
[5] Organization of cytoskeletal F-actin, G-actin, and gelsolin in the adhesion structures in cultured osteoclast
Akisaka, T
Yoshida, H
Inoue, S
Shimizu, K
JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (07) : 1248 - 1255
[6] THE ACCESSIBILITY OF ETHENONUCLEOTIDES TO COLLISIONAL QUENCHERS AND THE NUCLEOTIDE CLEFT IN G-ACTIN AND F-ACTIN
ROOT, DD
REISLER, E
PROTEIN SCIENCE, 1992, 1 (08) : 1014 - 1022
[7] COMPARISONS OF ENDOTHELIAL-CELL G-ACTIN AND F-ACTIN DISTRIBUTION IN SITU AND INVITRO
DUBOSE, DA
HAUGLAND, R
BIOTECHNIC & HISTOCHEMISTRY, 1993, 68 (01) : 8 - 16
[8] The second ADF/cofilin actin-binding site exists in F-actin, the cofilin-G-actin complex, but not in G-actin
Blondin, L
Sapountzi, V
Maciver, SK
Renoult, C
Benyamin, Y
Roustan, C
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (24): : 6426 - 6434
[9] Circular F-actin bundles and a G-actin gradient in pollen and pollen tubes of Lilium davidii
Li, Y
Zee, SY
Liu, YM
Huang, BQ
Yen, LF
PLANTA, 2001, 213 (05) : 722 - 730
[10] G-actin binding and F-actin bundling: novel functions of the V-ATPase subunit C
Vitavska, O.
Merzendorfer, H.
Wieczorek, H.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 2005, 141 (03): : S114 - S114

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