Sulphur Doped Graphitic Carbon Nitride as a Dual Biosensing Platform for the Detection of Cancer Biomarker CA15-3

被引：25
作者：
Sakthivel, Arunkumar [1 ,2 ]
Chandrasekaran, Anitha [1 ,2 ]
Sadasivam, Mohanraj [1 ]
Manickam, Pandiaraj [1 ,2 ]
Alwarappan, Subbiah [1 ,2 ]
机构：
[1] CSIR Cent Electrochem Res Inst, Karaikkudi 630003, Tamil Nadu, India
[2] Acad Sci & Innovat Res, Ghaziabad 201002, Uttar Pradesh, India
来源：
JOURNAL OF THE ELECTROCHEMICAL SOCIETY | 2021年 / 168卷 / 01期
关键词：
CA; 15-3; cancer biomarker; electrochemical biosensors; LABEL-FREE; NANOSHEETS; IMMUNOASSAY; SENSOR; DOTS; NI; CU;
D O I：
10.1149/1945-7111/abd927
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
Herein, we report a dual biosensing platform operating viz., electrochemical and fluorescence mode for the cancer biomarker, CA15-3 detection. A one-step strategy was employed to synthesize sulphur doped graphitic carbon nitride nanosheets (S-g-C3N4). The presence of heteroatom (sulphur) in the molecular structure improved the optoelectronic properties and the surface functional group (-NH2) facilitated the covalent binding of antibodies and improved the selectivity during the analysis. The proposed biosensing platform was able to quantify very low concentration of the cancer biomarker, CA15-3 (2.9 U mL(-1)) in human serum samples and thereby evidenced the usefulness of this platform for clinical analysis and early disease diagnosis.
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页数：8
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