D1 dopamine receptor activation reduces extracellular glutamate and GABA concentrations in the medial prefrontal cortex

被引：55
|
作者：
Abekawa, T
Ohmori, T
Ito, K
Koyama, T
机构：
[1] Hokkaido Univ, Sch Med, Dept Psychiat, Kita Ku, Sapporo, Hokkaido 0608638, Japan
[2] Univ Tokushima, Sch Med, Dept Neuropsychiat, Tokushima 770, Japan
来源：
BRAIN RESEARCH | 2000年 / 867卷 / 1-2期
关键词：
medial prefrontal cortex; D1 dopamine receptor; glutamate; alpha-aminobutyric acid; microdialysis;
D O I：
10.1016/S0006-8993(00)02298-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The present study examined effect of administration of a selective D1 dopamine receptor agonist. SKF38393 on extracellular concentrations of glutamate (Glu) and gamma-aminobutyric acid (GABA) in mPFC, by using in vivo microdialysis. Perfusion with SKF38393 via a dialysis probe reduced concentrations of both Glu and GABA dose-relatedly, and these effects were prevented by co-perfusion with a D1 dopamine receptor antagonist, SCH23390 (40 mu M) These results suggested that the dopaminergic hyperactivity may lead to the hypofunction of glutamatergic and GABAergic systems in mPFC via D1 dopamine receptor stimulation. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：250 / 254
页数：5
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