A mechanochemical theory for the ATP-fuelled biomolecular motors

被引：0
|
作者：
Liu, Ming S. [1 ,2 ]
Todd, B. D. [1 ]
Sadus, Richard J. [1 ]
机构：
[1] Swinburne Univ Technol, Ctr Mol Simulat, Hawthorn, Vic 3122, Australia
[2] CSIRO Math & Informat Sci, Clayton 3169, Australia
来源：
INTERNATIONAL JOURNAL OF NANOTECHNOLOGY | 2009年 / 6卷 / 12期
基金：
澳大利亚研究理事会;
关键词：
biomolecular motors; mechanochemistry; ATPase; enzymetics; Langevin dynamics; operating dynamics; F-1-ATPASE MOLECULAR MOTOR; COOPERATIVITY; HYDROLYSIS;
D O I：
10.1504/IJNT.2009.028468
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Biomolecular motors are normally single or complex biomolecules exerting mechanical forces over molecular and cellular scales. The ATP-fuelled biomolecular motors can transduce the chemical energy from ATP hydrolysis into forces and motions in cells. In biomolecular motors, transport reactions are both stoichiometric and enzymatic. We outline a mechanochemical theoretical framework for biomolecular motors to understand their enzymatic kinetics and continuous dynamics. The theory is validated by describing the operating mechanism and dynamics of several ATP-fuelled molecular motors driving various loads.
引用
收藏
页码：1121 / 1130
页数：10
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