Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description

Background. Mammary analog secretory carcinoma of the salivary glands (MASC(SG)) is a newly introduced malignant tumor of the salivary glands. For decades, it has been confused with acinic cell carcinoma (ACC) of the salivary glands. Methods. All reported cases of MASC(SG) were surveyed from 2010 until January 2017. The collected data was compiled and computationally processed to describe the clinical parameters of MASC(SG). Its epidemiology was also mapped. Moreover, inaccurate data was highlighted. Results. Clinically implicating, this article tackles simply the several clinical findings of MASC(SG) so that our contemporary nosology, at 7 years after description, can be updated. The cytogenetic, histologic, and immunohistochemical details are also defined. Conclusion. The available data about MASC(SG) is sufficient enough to diagnose it with no need to investigate the ETV6-NTRK3 translocation. Although high-grade malignancy and distant metastases were rarely reported, a rapt attention should be paid both to the nature of this tumor and to the indicated close follow-up of such cases, especially when necrosis, increased mitotic activity, and other classic caveats are conspicuous. (C) 2017 Wiley Periodicals, Inc.