Secondary Effects of Antipsychotics: Women at Greater Risk Than Men

被引:120
作者
Seeman, Mary V. [1 ]
机构
[1] Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada
关键词
antipsychotics side effects; women; cardiovascular risk; autoimmunity; thromboembolism; malignancy; blood dyscrasia; CORONARY-HEART-DISEASE; RISPERIDONE PLASMA-CONCENTRATIONS; POSTMENOPAUSAL BREAST-CANCER; POPULATION-BASED COHORT; BONE-MINERAL DENSITY; INDUCED WEIGHT-GAIN; TORSADE-DE-POINTES; BODY-MASS INDEX; METABOLIC SYNDROME; ATYPICAL ANTIPSYCHOTICS;
D O I
10.1093/schbul/sbn023
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Context: The health burden of antipsychotic medication is well known, but the disproportionate effect on women as compared with men is underappreciated. Objective: The goal of this article is preventive-to better inform clinicians so that the risks to women and to their offspring can be diminished. Method: All PubMed sources in which the search term gender (or sex) was linked to a side effect of antipsychotic medication were reviewed. Result: There is general agreement in the literature on women's increased susceptibility to weight gain, diabetes, and specific cardiovascular risks of antipsychotics, with less consensus on malignancy risks and risks to the fetus. Cardiovascular death, to which men are more susceptible than women, is disproportionately increased in women by the use of antipsychotics. Sedating antipsychotics raise the risk of embolic phenomena during pregnancy, and postpartum. Prolactin-elevating drugs suppress gonadal hormone secretion and may enhance autoimmune proclivity. Conclusions: Clinicians need to be aware of the differential harm that women (and their offspring) can incur from the side effects of antipsychotics.
引用
收藏
页码:937 / 948
页数:12
相关论文
共 117 条
[31]   Diabetes and risk of endometrial cancer: A population-based prospective cohort study [J].
Friberg, Emilie ;
Mantzoros, Christos S. ;
Wolk, Alicja .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (02) :276-280
[32]   Anthropometric factors and risk of endometrial cancer:: the European prospective investigation into cancer and nutrition [J].
Friedenreich, Christine ;
Cust, Anne ;
Lahmann, Petra H. ;
Steindorf, Karen ;
Boutron-Ruault, Marie-Christine ;
Clavel-Chapelon, Francoise ;
Mesrine, Sylvie ;
Linseisen, Jakob ;
Rohrmann, Sabine ;
Boeing, Heiner ;
Pischon, Tobias ;
Tjonneland, Anne ;
Halkjaer, Jytte ;
Overvad, Kim ;
Mendez, Michelle ;
Redondo, M. L. ;
Martinez Garcia, Carmen ;
Larranaga, Nerea ;
Tormo, Maria-Jose ;
Gurrea, Aurelio Barricarte ;
Bingham, Sheila ;
Khaw, Kay-Tee ;
Allen, Naomi ;
Key, Tim ;
Trichopoulou, Antonia ;
Vasilopoulou, Effie ;
Trichopoulos, Dimitrios ;
Pala, Valeria ;
Palli, Domenico ;
Tumino, Rosario ;
Mattiello, Amalia ;
Vineis, Paolo ;
Bueno-de-Mesquita, H. Bas ;
Peeters, Petra H. M. ;
Berglund, Goran ;
Manjer, Jonas ;
Lundin, Eva ;
Lukanova, Annekatrin ;
Slimani, Nadia ;
Jenab, Mazda ;
Kaaks, Rudolf ;
Riboli, Elio .
CANCER CAUSES & CONTROL, 2007, 18 (04) :399-413
[33]   Long-term treatment with atypical antipsychotics and the risk of weight gain - A literature analysis [J].
Gentile, S .
DRUG SAFETY, 2006, 29 (04) :303-319
[34]   A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls [J].
Goff, DC ;
Sullivan, LM ;
McEvoy, JP ;
Meyer, JM ;
Nasrallah, HA ;
Daumit, GL ;
Lamberti, S ;
D'Agostino, RB ;
Stroup, TS ;
Davis, S ;
Lieberman, JA .
SCHIZOPHRENIA RESEARCH, 2005, 80 (01) :45-53
[35]   Mortality trends in men and women with diabetes, 1971 to 2000 [J].
Gregg, Edward W. ;
Gu, Qiuping ;
Cheng, Yiling J. ;
Narayan, Venkat ;
Cowie, Catherine C. .
ANNALS OF INTERNAL MEDICINE, 2007, 147 (03) :149-155
[36]   Use of maternal GHb concentration to estimate the risk of congenital anomalies in the offspring of women with prepregnancy diabetes [J].
Guerin, Andrea ;
Nisenbaum, Rosane ;
Ray, Joel G. .
DIABETES CARE, 2007, 30 (07) :1920-1925
[37]   Antipsychotic-related QTc prolongation, Torsade de Pointes and sudden death [J].
Haddad, PM ;
Anderson, IM .
DRUGS, 2002, 62 (11) :1649-1671
[38]  
Hägg S, 2002, CNS DRUGS, V16, P765
[39]   Osteoporosis, schizophrenia and antipsychotics - The need for a comprehensive multifactorial evaluation [J].
Halbreich, Uriel .
CNS DRUGS, 2007, 21 (08) :641-657
[40]   Hyperprolactinaemia as an adverse effect in regulatory and clinical toxicology: role in breast and prostate cancer [J].
Harvey, P. W. ;
Everett, D. J. ;
Springall, C. J. .
HUMAN & EXPERIMENTAL TOXICOLOGY, 2006, 25 (07) :395-404