A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus

被引：66

作者：

Inman, Wayne D. ^{[1
]}

Bray, Walter M. ^{[2
]}

Gassner, Nadine C. ^{[2
]}

Lokey, R. Scott ^{[1
,2
]}

Tenney, Karen ^{[1
]}

Shen, Young Yongchun ^{[3
]}

TenDyke, Karen ^{[3
]}

Suh, Ted ^{[3
]}

Crews, Phillip ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

[2] Univ Calif Santa Cruz, UCSC Chem Screening Ctr, Santa Cruz, CA 95064 USA

[3] Eisai Res Inst, Andover, MA 01810 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 02期

关键词：

ANTINEOPLASTIC AGENTS; INHIBITOR; PUUPEHENONE; ERECTA;

D O I：

10.1021/np9005426

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid. named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure Was elucidated front spectroscopic data, including H-1-N-15 HMBC NMR experiments, Which provided complementary N-15 chemical shift information ill support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.

引用

页码：255 / 257

页数：3

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