Comparison of the Utility of Total Plasma Fatty Acids Versus those in Cholesteryl Ester, Phospholipid, and Triglyceride as Biomarkers of Fatty Acid Intake

被引:37
作者
Furtado, Jeremy D. [1 ]
Beqari, Jorind [1 ]
Campos, Hannia [1 ]
机构
[1] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Nutr Biomarker Lab, 665 Huntington Ave, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
dietary fat; biomarker; fatty acids; plasma; cholesteryl ester; phospholipid; triglyceride; free fatty acid; CORONARY-HEART-DISEASE; ADIPOSE-TISSUE; DAIRY FAT; CIRCULATING BIOMARKERS; SERUM-LIPIDS; US MEN; RISK; BLOOD; SEPARATION; FREQUENCY;
D O I
10.3390/nu11092081
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Total plasma fatty acids or those in cholesteryl ester and phospholipids are often used to reflect fatty acid intake in epidemiological studies, but their relative performance as biomarkers of intake has not been clearly evaluated within a single population. The assessment of fatty acids in plasma fractions is more labor intensive. Thus, their use as biomarkers of dietary intake needs to be justified. Dietary intake was assessed in 200 population-based controls from a case-control study of diet and heart disease in Costa Rica by a validated food frequency questionnaire (FFQ). Fatty acids in fasting whole plasma and plasma fractions (cholesteryl ester, phospholipid, and triglyceride + free fatty acid) were measured in the 200 controls by the same laboratory using gas chromatography with flame ionization detection (GC-FID). We compared the plasma and plasma fractions data with the FFQ and adipose fatty acid profile using partial Spearman correlations to assess utility as biomarkers of intake and exposure. We found that whole plasma was equally or more strongly correlated with the FFQ and adipose fatty acid profile than either cholesteryl ester or phospholipid in most of the established markers of dietary intake, including dairy (15:0 and 17:0) and seafood (eicosapentaenoic acid and docosahexaenoic acid). Of the three plasma fractions, only fatty acids in the plasma triglyceride + free fatty acid fraction had stronger correlations with dietary intake than whole plasma. In our study population, fatty acids measured in fasting whole plasma perform as good as or better than those measured in plasma fractions as biomarkers for dietary fatty acid intake. Thus, the fractionation of plasma to evaluate long-term fatty acid intake may not be warranted.
引用
收藏
页数:17
相关论文
共 51 条
[1]  
AGREN JJ, 1992, J LIPID RES, V33, P1871
[2]   Blood levels of long-chain n-3 fatty acids and the risk of sudden death. [J].
Albert, CM ;
Campos, H ;
Stampfer, MJ ;
Ridker, PM ;
Manson, JE ;
Willett, WC ;
Ma, J .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (15) :1113-1118
[3]   Biomarkers and the measurement of fatty acids [J].
Arab, L ;
Akbar, J .
PUBLIC HEALTH NUTRITION, 2002, 5 (6A) :865-871
[4]   FATTY-ACID COMPOSITION OF SERUM-LIPIDS AND ITS RELATION TO DIET IN AN ELDERLY INSTITUTIONALIZED POPULATION [J].
ASCIUTTIMOURA, LS ;
GUILLAND, JC ;
FUCHS, F ;
RICHARD, D ;
KLEPPING, J .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1988, 48 (04) :980-987
[5]   Dietary fat and semen quality among men attending a fertility clinic [J].
Attaman, Jill A. ;
Toth, Thomas L. ;
Furtado, Jeremy ;
Campos, Hannia ;
Hauser, Russ ;
Chavarro, Jorge E. .
HUMAN REPRODUCTION, 2012, 27 (05) :1466-1474
[6]   Fasting whole blood as a biomarker of essential fatty acid intake in epidemiologic studies: Comparison with adipose tissue and plasma [J].
Baylin, A ;
Kim, MK ;
Donovan-Palmer, A ;
Siles, X ;
Dougherty, L ;
Tocco, P ;
Campos, H .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2005, 162 (04) :373-381
[7]   Adipose tissue biomarkers of fatty acid intake [J].
Baylin, A ;
Kabagambe, EK ;
Siles, X ;
Campos, H .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2002, 76 (04) :750-757
[8]   The use of fatty acid biomarkers to reflect dietary intake [J].
Baylin, Ana ;
Campos, Hannia .
CURRENT OPINION IN LIPIDOLOGY, 2006, 17 (01) :22-27
[9]   RAPID SAMPLING AND LONG-TERM STORAGE OF SUBCUTANEOUS ADIPOSE-TISSUE BIOPSIES FOR DETERMINATION OF FATTY-ACID COMPOSITION [J].
BEYNEN, AC ;
KATAN, MB .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1985, 42 (02) :317-322
[10]   Best practices for the design, laboratory analysis, and reporting of trials involving fatty acids [J].
Brenna, J. Thomas ;
Plourde, Melanie ;
Stark, Ken D. ;
Jones, Peter J. ;
Lin, Yu-Hong .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2018, 108 (02) :211-227