Formation and Biopharmaceutical Characterization of Electrospun PVP Mats with Propolis and Silver Nanoparticles for Fast Releasing Wound Dressing

被引：27

作者：

Adomaviciute, Erika ^{[1
]}

Stanys, Sigitas ^{[1
]}

Zilius, Modestas ^{[2
]}

Juskaite, Vaida ^{[2
]}

Pavilonis, Alvydas ^{[3
]}

Briedis, Vitalis ^{[2
]}

机构：

[1] Kaunas Univ Technol, Fac Mech Engn & Design, Dept Mat Engn, Studentu 56, LT-51424 Kaunas, Lithuania

[2] Lithuanian Univ Hlth Sci, Dept Clin Pharm, Fac Pharm, Sukileliu Pr 13, LT-50161 Kaunas, Lithuania

[3] Lithuanian Univ Hlth Sci, Inst Microbiol & Virol, Eiveniu G 4, LT-50161 Kaunas, Lithuania

来源：

BIOMED RESEARCH INTERNATIONAL | 2016年 / 2016卷

关键词：

IN-SITU SYNTHESIS; NANOFIBER MATS; ANTIMICROBIAL ACTIVITY; FABRICATION; VITRO;

D O I：

10.1155/2016/4648287

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, and anticancer activities of propolis and its ability to stimulate the immune system and promote wound healing make it a proper component for wound dressing materials. Silver nanoparticles are recognized to demonstrate strong antiseptic and antimicrobial activity; thus, it also could be considered in the development of products for wound healing. Combining propolis and silver nanoparticles can result in improved characteristics of products designed for wound healing and care. The aim of this study was to formulate electrospun fast dissolving mats for wound dressing containing propolis ethanolic extract and silver nanoparticles. Produced electrospun nano/microfiber mats were evaluated studying their structure, dissolution rate, release of propolis phenolic compounds and silver nanoparticles, and antimicrobial activity. Biopharmaceutical characterization of electrospun mats demonstrated fast release of propolis phenolic compounds and silver nanoparticles. Evaluation of antimicrobial activity on Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Bacillus subtilis, Bacillus cereus, and Candida albicans strains confirmed the ability of electrospun mats to inhibit the growth of the tested microorganisms.

引用

页数：11

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