Accuracy of ultrasonography and 99mTc-sestamibi scintimammography for assessing axillary lymph node status in breast cancer patients.: A prospective study

Ainis: The aim of this study was to evaluate the sensitivity, specificity and accuracy of axillary ultrasonography (US) and Tc-99m-sestamibi scintimammography (SSM) in patients with breast cancer (BC) undergoing curative surgery. Methods: A series of 77 consecutive women (median age 54 years, range 36-70) with primary BC underwent both US and SSM from 2 to 15 (median 4) days prior to curative surgery. The results of imaging studies were compared against the final pathology. Breast-conserving surgery with axillary node (AN) dissection was performed in 49 (63.6%) patients, and modified radical mastectomy in 28 (36.4%) patients, according to the tumour staging. Results: Final pathology showed 5 pT1bN0, 1 pTlbN0, 28 pT1cN0, 19 pT1cN1, 7 pT2N0, and 17 pT2N1 BC. Overall, 719 AN were removed of which 106 (14.7%) were metastatized nodes (median 3, range 1-5 per patient). The sensitivity, specificity and accuracy were 67.6%, 80.0%, and 74.0% for US, 78.4%, 85.0%, and 81.8% for SSM, and 91.9%, 92.5%, and 92.2% for US and SSM together, respectively. There was a significant difference (p < 0.05) in the number of metastatized AN between patients with metastases correctly detected and undetected by both US (3.1 +/- 1.3 vs. 2.0 +/- 0.7) and SSM (3.2 +/- 1.3 vs. 1.7 +/- 0.7). Conclusions: Although the results of each diagnostic tests are strictly dependent on the number of the metastatized AN, the combination of axillary US and SSM is a sensitive low-cost procedure that should be suggested in all patients with BC, when a preoperative evaluation of the AN status is required. (c) 2006 Elsevier Ltd. All rights reserved.