Catalyzed Propargylic Substitution

被引：237

作者：

Detz, Remko J. ^{[1
]}

Hiemstra, Henk ^{[1
]}

van Maarseveen, Jan H. ^{[1
]}

机构：

[1] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1018 WS Amsterdam, Netherlands

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 36期

关键词：

Alkynes; Copper; Enantioselectivity; Ruthenium; ONE-POT SYNTHESIS; PROPARGYLATION/CYCLOISOMERIZATION TANDEM REACTION; BRIDGED DIRUTHENIUM COMPLEXES; BOND-FORMING REACTIONS; NUCLEOPHILIC-SUBSTITUTION; 1,3-DICARBONYL COMPOUNDS; CENTERED NUCLEOPHILES; RUTHENIUM CATALYSTS; ALLYLIC ALKYLATIONS; AROMATIC-COMPOUNDS;

D O I：

10.1002/ejoc.200900877

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Besides being a versatile entity for further chemical transformations, the propargylic subunit is also part of various natural products, fine chemicals, and synthetic pharmaceuticals. Propargylic substitution reactions, however, are rather unexplored. An overview of this emerging field is presented. We especially focus on experimental results that deal with catalyzed substitutions of propargylic alcohols and their derivatives. Finally, some enantioselective propargylic substitution methods are discussed. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

引用

页码：6263 / 6276

页数：14

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