(Poly)phenols in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Review

被引：22

作者：

Hagan, Marilyn ^{[1
]}

Hayee, Bu' Hussain ^{[2
]}

Rodriguez-Mateos, Ana ^{[3
]}

机构：

[1] Royal Papworth Hosp NHS Fdn Trust, Dept Nutr & Dietet, Cambridge CB2 0AY, England

[2] Kings Coll Hosp NHS Fdn Trust, Dept Gastroenterol, London SE5 9RS, England

[3] Kings Coll London, Dept Nutr Sci, Fac Life Sci & Med, London WC2R 2LS, England

来源：

MOLECULES | 2021年 / 26卷 / 07期

关键词：

inflammatory bowels disease (IBD); Crohn’ s disease; ulcerative colitis; irritable bowel syndrome (IBS); (poly)phenols; QUALITY-OF-LIFE; MODERATE ULCERATIVE-COLITIS; GASTROINTESTINAL SYMPTOMS; DOUBLE-BLIND; 5-AMINOSALICYLIC ACID; CROHNS-DISEASE; INTESTINAL PERMEABILITY; DIETARY POLYPHENOLS; URINARY SUCRALOSE; CLINICAL-TRIAL;

D O I：

10.3390/molecules26071843

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Poly)phenols (PPs) may have a therapeutic benefit in gastrointestinal (GI) disorders, such as irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). The aim of this review is to summarise the evidence-base in this regard. Observational evidence does not give a clear indication that PP intake has a preventative role for IBD or IBS, while interventional studies suggest these compounds may confer symptomatic and health-related quality of life improvements in known patients. There are inconsistent results for effects on markers of inflammation, but there are promising reports of endoscopic improvement. Work on the effects of PPs on intestinal permeability and oxidative stress is limited and therefore conclusions cannot be formed. Future work on the use of PPs in IBD and IBS will strengthen the understanding of clinical and mechanistic effects.

引用

页数：21

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