Synthetic approaches towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol)

被引：11

作者：

Saddique, FunIan Ahmad ^{[1
]}

Zahoor, Ameer Fawad ^{[1
]}

Yousaf, Muhammad ^{[1
]}

Irfan, Muhammad ^{[2
]}

Ahmad, Matloob ^{[1
]}

Mansha, Asim ^{[1
]}

Khan, Zulfiqar Ali ^{[1
]}

Naqvi, Syed Ali Raza ^{[1
]}

机构：

[1] Govt Coll Univ, Dept Chem, Faisalabad, Pakistan

[2] Govt Coll Univ, Fac Pharmaceut Sci, Dept Pharmaceut, Faisalabad, Pakistan

来源：

TURKISH JOURNAL OF CHEMISTRY | 2016年 / 40卷 / 02期

关键词：

Beta-blockers; cardiovascular activity; antiglaucoma agent; biotransformations; ASYMMETRIC NITROALDOL REACTION; HYDROLYTIC KINETIC RESOLUTION; ADRENERGIC BLOCKING-AGENT; LIPASE-CATALYZED RESOLUTION; IMPROVED OCULAR DELIVERY; TERMINAL EPOXIDES; PRACTICAL SYNTHESIS; ENANTIOSELECTIVE PREPARATION; CONVENIENT SYNTHESIS; CONCISE SYNTHESIS;

D O I：

10.3906/kim-1504-65

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Numerous efficient synthetic methodologies have been elaborated for the synthesis of beta-blockers since the introduction of propranolol (a beta-blocker) in 1968. In this review, focus is placed on the more concise asymmetric and bioenzymatic synthetic approaches attempted towards the synthesis of beta-blockers (betaxolol, metoprolol, sotalol, and timolol).

引用

页码：193 / 224

页数：32

共 13 条

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