An update on PTEN modulators - a patent review

被引：39

作者：

Boosani, Chandra S. ^{[1
]}

Gunasekar, Palanikumar ^{[2
]}

Agrawal, Devendra K. ^{[1
]}

机构：

[1] Western Univ Hlth Sci, Dept Translat Res, 615 East,3rd St,Daumier Bldg,Room 143, Pomona, CA 91766 USA

[2] Creighton Univ, Sch Med, Dept Clin & Translat Sci, Omaha, NE USA

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2019年 / 29卷 / 11期

基金：

美国国家卫生研究院;

关键词：

PTEN regulators; peptides; chemical compounds; viral vectors; human diseases; AXON REGENERATION; OPTIC-NERVE; TUMOR-SUPPRESSOR; PARTIAL RECOVERY; CO-DELETION; STEM-CELLS; ACTIVATION; APOPTOSIS; PHOSPHORYLATION; INHIBITION;

D O I：

10.1080/13543776.2019.1669562

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Introduction: A multitude of cellular and physiological functions have been attributed to the biological activity of PTEN (Phosphatase and tensin homolog) such as inhibiting angiogenesis, promoting apoptosis, preventing cell proliferation, and maintaining cellular homeostasis. Based on whether cell growth is needed to be initiated or to be inhibited, enhancing PTEN expression or seeking to inhibit it was pursued. Areas covered: Here the authors provide recent updates to their previous publication on 'PTEN modulators: A patent review', and discuss on new specificities that affirm the therapeutic potential of PTEN in promoting neuro-regeneration, stem cell regeneration, autophagy, bone and cartilage regeneration. Also, targeting PTEN appears to be effective in developing new treatment strategies for Parkinson's disease, Alzheimer's disease, macular degeneration, immune disorders, asthma, arthritis, lupus, Crohn's disease, and several cancer types. Expert opinion: PTEN mainly inhibits the PI3k/Akt pathway. However, the PI3k/Akt pathway can be activated by other signaling proteins. Thus, novel treatment strategies that can regulate PTEN alone, or combinational treatment approaches that can induce PTEN and simultaneously affect downstream mediators in the PI3K/Akt pathway, are needed, which were not investigated in detail. Commercial interests associated with molecules that regulate PTEN are discussed here, along with limitations and new possibilities to improve them.

引用

页码：881 / 889

页数：9

共 59 条

[1] PTEN modulators: a patent review [J].

Boosani, Chandra S. ;

Agrawal, Devendra K. .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2013, 23 (05) :569-580

[2] FAK and p38-MAP Kinase-Dependent Activation of Apoptosis and Caspase-3 in Retinal Endothelial Cells by α1(IV)NC1 [J].

Boosani, Chandra S. ;

Nalabothula, Narasimharao ;

Munugalavadla, Veerendra ;

Cosgrove, Dominic ;

Keshamoun, Venkateshwar G. ;

Sheibani, Nader ;

Sudhakar, Akulapalli .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2009, 50 (10) :4567-4575

[3] RETRACTED: Inhibitory Effects of Arresten on bFGF-Induced Proliferation, Migration, and Matrix Metalloproteinase-2 Activation in Mouse Retinal Endothelial Cells (Retracted Article) [J].

Boosani, Chandra Shekar ;

Nalabothula, Narasimharao ;

Sheibani, Nader ;

Sudhakar, Akulapalli .

CURRENT EYE RESEARCH, 2010, 35 (01) :45-55

[4] PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons [J].

Christie, Kimberly J. ;

Webber, Christine A. ;

Martinez, Jose A. ;

Singh, Bhagat ;

Zochodne, Douglas W. .

JOURNAL OF NEUROSCIENCE, 2010, 30 (27) :9306-9315

[5]

Dave VG, 2018, US patent, Patent No. [WO2018151835A1, 2018151835]

[6] Combinatorial Therapy Stimulates Long-Distance Regeneration, Target Reinnervation, and Partial Recovery of Vision After Optic Nerve Injury in Mice [J].

de Lima, Silmara ;

Habboub, Ghaith ;

Benowitz, Larry I. .

AXON GROWTH AND REGENERATION, PT 2, 2012, 106 :153-172

[7] Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors [J].

de Lima, Silmara ;

Koriyama, Yoshiki ;

Kurimoto, Takuji ;

Oliveira, Julia Teixeira ;

Yin, Yuqin ;

Li, Yiqing ;

Gilbert, Hui-Ya ;

Fagiolini, Michela ;

Blanco Martinez, Ana Maria ;

Benowitz, Larry .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (23) :9149-9154

[8] PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype [J].

Duan, Shunlei ;

Yuan, Guohong ;

Liu, Xiaomeng ;

Ren, Ruotong ;

Li, Jingyi ;

Zhang, Weizhou ;

Wu, Jun ;

Xu, Xiuling ;

Fu, Lina ;

Li, Ying ;

Yang, Jiping ;

Zhang, Weiqi ;

Bai, Ruijun ;

Yi, Fei ;

Suzuki, Keiichiro ;

Gao, Hua ;

Esteban, Concepcion Rodriguez ;

Zhang, Chuanbao ;

Belmonte, Juan Carlos Izpisua ;

Chen, Zhiguo ;

Wang, Xiaomin ;

Jiang, Tao ;

Qu, Jing ;

Tang, Fuchou ;

Liu, Guang-Hui .

NATURE COMMUNICATIONS, 2015, 6

[9] Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice [J].

Gallaher, Zachary R. ;

Steward, Oswald .

EXPERIMENTAL NEUROLOGY, 2018, 303 :120-133

[10] Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain [J].

Huang, Shi-Ying ;

Sung, Chun-Sung ;

Chen, Wu-Fu ;

Chen, Chun-Hong ;

Feng, Chien-Wei ;

Yang, San-Nan ;

Hung, Han-Chun ;

Chen, Nan-Fu ;

Lin, Pey-Ru ;

Chen, San-Cher ;

Wang, Hui-Min David ;

Chu, Tian-Huei ;

Tai, Ming-Hong ;

Wen, Zhi-Hong .

JOURNAL OF NEUROINFLAMMATION, 2015, 12

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