Longitudinal analysis of meibomian gland dropout in patients with ocular graft-versus-host disease

Purpose: To evaluate morphological changes in meibomian glands (MGs) over 1 year in patients diagnosed with chronic ocular graft-versus-host disease (GVHD), and to determine the association between MG loss and ocular surface parameters in such patients. Methods: This retrospective, observational study included 37 patients diagnosed with ocular GVHD who were followed-up for at least 1 year in the ophthalmology department. All patients received treatment during the follow-up period. The Ocular Surface Disease Index (OSDI) score, tear breakup time (TBUT), corneal staining score, lid margin score, Schirmer test I value, and noncontact infrared meibography findings were evaluated at baseline and after 1 year of follow-up for ocular GVHD. Both eyes were included in the analyses. Results: OSDI (p = 0.0391), corneal fluorescein scores (p = 0.0352 and 0.0181 for the right and left eyes, respectively), and upper and lower eyelid meiboscores (right eye: p = 0.0039 and 0.0156, respectively: left eye: p = 0.0273 and 0.0156, respectively) were significantly higher at 1 year than at baseline. Infrared meibography showed MG loss in 18.9% of eyes, improvement in 5.4% of eyes, and no changes in 75.7% of eyes, respectively. The Schirmer value for the right eye negatively correlated with the upper eyelid meiboscore at 1 year (p = 0.0103, r = - 0.46), whereas the corneal fluorescein score for the left eye positively correlated with both upper and lower eyelid meiboscores at 1 year (p = 0.0368, r = 0.40; p = 0.0387, r = 0.39, respectively). Conclusions: Rapid and aggressive MG destruction may occur in patients with ocular GVHD. Further studies with larger patient samples and longer follow-up periods are mandatory to validate these conclusions.