Stevia rebaudiana Bertoni bioactive effects: From in vivo to clinical trials towards future therapeutic approaches

被引：31

作者：

Salehi, Bahare ^{[1
]}

Dolores Lopez, Maria ^{[2
]}

Martinez-Lopez, Sara ^{[3
]}

Victoriano, Montserrat ^{[4
]}

Sharifi-Rad, Javad ^{[5
]}

Martorell, Miquel ^{[4
]}

Rodrigues, Celia F. ^{[6
]}

Martins, Natalia ^{[7
,8
]}

机构：

[1] Bam Univ Med Sci, Sch Med, Student Res Comm, Bam, Iran

[2] Univ Concepcion, Fac Agron, Dept Plant Prod, Chillan, Chile

[3] European Univ Madrid UEM, Sch Biomed Sci, Dept Pharm Biotechnol & Nutr, Madrid, Spain

[4] Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion, Chile

[5] Zabol Univ Med Sci, Zabol Med Plants Res Ctr, Zabol, Iran

[6] Univ Porto, Fac Engn, Dept Chem Engn, LEPABE, Porto, Portugal

[7] Univ Porto, Fac Med, Porto, Portugal

[8] Univ Porto, Inst Res & Innovat Hlth i3S, Porto, Portugal

来源：

PHYTOTHERAPY RESEARCH | 2019年 / 33卷 / 11期

关键词：

food-derived applications; health promotion; phytopharmacological potential; Stevia rebaudiana Bertoni; PLANT-DERIVED DIHYDROISOSTEVIOL; STIMULATES INSULIN-SECRETION; PANCREATIC BETA-CELLS; DITERPENE GLYCOSIDES; REBAUDIOSIDE-A; NITROGEN-FERTILIZATION; ANTIOXIDANT PROPERTIES; LIQUID-CHROMATOGRAPHY; SWEETENERS STEVIOSIDE; GLUCOSE-ABSORPTION;

D O I：

10.1002/ptr.6478

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stevia rebaudiana Bertoni, a plant from South America and indigenous of Paraguay, has shown several biological effects and healthy properties, although it is especially used in South America and some Asiatic regions. In addition, it is a natural sweetener, almost 300 times sweeter than sucrose, being attributed to its phytoconstituents prominent antioxidant, antimicrobial, antidiabetic (antihyperglycemic, insulinotropic, and glucagonostatic), antiplatelet, anticariogenic, and antitumor effects. In this sense, this work aims to provide an extensive overview on the historical practices of stevia and its effects in human health based on its chemical composition and applications for both food and pharmaceutical industries.

引用

页码：2904 / 2917

页数：14

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