Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease

被引：39

作者：

Girard, Romuald ^{[1
]}

Khanna, Omaditya ^{[1
]}

Shenkar, Robert ^{[1
]}

Zhang, Lingjiao ^{[1
]}

Wu, Meijing ^{[1
]}

Jesselson, Michael ^{[1
]}

Zeineddine, Hussein A. ^{[1
]}

Gangal, Anupriya ^{[1
]}

Fam, Maged D. ^{[1
]}

Gibson, Christopher C. ^{[2
]}

Whitehead, Kevin J. ^{[3
,4
]}

Li, Dean Y. ^{[3
,4
]}

Liao, James K. ^{[5
]}

Shi, Changbin ^{[1
]}

Awad, Issam A. ^{[1
]}

机构：

[1] Univ Chicago Med, Neurosurg Sect, Neurovasc Surg Program, 5841 S Maryland Ave, Chicago, IL 60637 USA

[2] Recurs Pharmaceut, Salt Lake City, UT 84108 USA

[3] Univ Utah, Sch Med, Div Cardiol, 30 N 1900 E, Salt Lake City, UT 84132 USA

[4] Univ Utah, Sch Med, Dept Med, 30 N 1900 E, Salt Lake City, UT 84132 USA

[5] Univ Chicago Med, Cardiol Sect, 5841 S Maryland Ave, Chicago, IL 60637 USA

来源：

BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 03期

关键词：

aggressiveness; biomarker; cerebral cavernous malformation; inflammation; non-HDL cholesterol; vitamin D; CARDIOVASCULAR RISK; NATURAL-HISTORY; HEMORRHAGE RISK; IMMUNE-RESPONSE; CLINICAL-COURSE; LIPID-LEVELS;

D O I：

10.2217/bmm.15.118

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.

引用

页码：255 / 264

页数：10

共 38 条

[1] Natural history and imaging prevalence of cavernous malformations in children and young adults Clinical article [J].