Bioadhesion and biocompatibility evaluations of gelatin and polyacrylic acid as a crosslinked hydrogel in vitro

被引：18

作者：

Ghavamzadeh, R ^{[1
]}

Haddadi-Asl, V ^{[1
]}

Mirzadeh, H ^{[1
]}

机构：

[1] Amirkabir Univ Technol, Dept Polymer Engn, Tehran, Iran

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2004年 / 15卷 / 08期

关键词：

polyacrylic acid; gelatin; water-soluble carbodimide; biological glue; hydrogel;

D O I：

10.1163/1568562041526478

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study describes the potentiality of crosslinked hydrogels comprised of gelatin and polyacrylic acid (CHGP) as a biological glue for soft tissues and compares its bonding strength with that of fibrin glue. Water-soluble carbodimide (WSC) was used to crosslink the mixture of gelatin and polyacrylic acid (PAA). An addition of PAA to gelatin increases bonding strength and reduces the gelation time and WSC concentration. Increasing the gelatin, WSC and PAA concentration increases the bonding strength. There is a critical concentration to have a maximum bonding strength. The cured hydrogel exhibited sufficient adhesion to mouse skin with a higher bonding strength than fibrin glue. The in vitro test has been done for evaluating CHGP toxicity.

引用

页码：1019 / 1031

页数：13

共 27 条

[1]

CHU JS, 1991, J PHARM RES, V18, P1408

[2] In vitro biocompatibility of biodegradable dextran-based hydrogels tested with human fibroblasts [J].

De Groot, CJ ;

Van Luyn, MJA ;

Van Dijk-Wolthuis, WNE ;

Cadée, JA ;

Plantinga, JA ;

Den Otter, W ;

Hennink, WE .

BIOMATERIALS, 2001, 22 (11) :1197-1203

[3] Tissues and bone adhesives - historical aspects [J].

Donkerwolcke, M ;

Burny, F ;

Muster, D .

BIOMATERIALS, 1998, 19 (16) :1461-1466

[4] EFFECTIVENESS OF A NEW NON-THROMBOGENIC BIO-ADHESIVE IN MICROVASCULAR ANASTOMOSES [J].

DOWBAK, GM ;

ROHRICH, RJ ;

ROBINSON, JB ;

PEDEN, E .

JOURNAL OF RECONSTRUCTIVE MICROSURGERY, 1994, 10 (06) :383-386

[5]

ETEMADI M, 1999, 4 NAT IR CHEM ENG C, P340

[6]

GIBBLE JW, 1990, J TRANSFUSION, V30, P740

[7]

GROSS L, 1985, HDB ADHESIVES, P818

[8] A novel surgical glue composed of gelatin and N-hydroxysuccinimide activated poly(L-glutamic acid):: Part 1.: Synthesis of activated poly(L-glutamic acid) and its gelation with gelatin [J].

Iwata, H ;

Matsuda, S ;

Mitsuhashi, K ;

Itoh, E ;

Ikada, Y .

BIOMATERIALS, 1998, 19 (20) :1869-1876

[9]

JABBARI E, 1999, P 26 INT S CONTR REL, P313

[10]

JABBARI E, 1999, P 26 INT S CONTR REL, P311

← 1 2 3 →