MiRNA-mediated EMT and CSCs in cancer chemoresistance

被引：71

作者：

Dong, Bing ^{[1
,2
]}

Li, Shiyu ^{[3
]}

Zhu, Shuangli ^{[3
]}

Yi, Ming ^{[3
]}

Luo, Suxia ^{[2
,4
]}

Wu, Kongming ^{[2
,3
,4
]}

机构：

[1] Zhengzhou Univ, Affiliated Canc Hosp, Dept Mol Pathol, Zhengzhou 450008, Peoples R China

[2] Henan Canc Hosp, Zhengzhou 450008, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Wuhan 430030, Peoples R China

[4] Zhengzhou Univ, Affiliated Canc Hosp, Dept Med Oncol, Zhengzhou 450008, Peoples R China

来源：

EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2021年 / 10卷 / 01期

基金：

中国国家自然科学基金;

关键词：

miRNA; EMT; CSCs; Chemoresistance;

D O I：

10.1186/s40164-021-00206-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer stem cells (CSCs) are a small group of cancer cells, which contribute to tumorigenesis and cancer progression. Cancer cells undergoing epithelial-to-mesenchymal transition (EMT) acquire the chemoresistant ability, which is regarded as an important feature of CSCs. Thus, there emerges an opinion that the generation of CSCs is considered to be driven by EMT. In this complex process, microRNAs (miRNAs) are found to play a key role. In order to overcome the drug resistance, inhibiting EMT as well as CSCs phenotype seem feasible. Thereinto, regulating the EMT- or CSCs-associated miRNAs is a crucial approach. Herein, we conduct this review to elaborate on the complicated interplay between EMT and CSCs in cancer chemoresistance, which is modulated by miRNAs. In addition, we elucidate the therapeutic strategy to overcome drug resistance through targeting EMT and CSCs.

引用

页数：12

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