Role and clinical significance of TGF-β1 and TGF-βR1 in malignant tumors (Review)

被引：83
作者：
Wang, Junmin [1 ]
Xiang, Hongjiao [1 ]
Lu, Yifei [1 ]
Wu, Tao [1 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, 1200 Cailun Rd, Shanghai 201203, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2021年 / 47卷 / 04期
基金：
中国国家自然科学基金;
关键词：
transforming growth factor-β 1; receptor; malignant tumor; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; ANAPLASTIC THYROID-CANCER; SMALL-MOLECULE INHIBITOR; REGULATORY T-CELLS; I KINASE INHIBITOR; TGF-BETA; BREAST-CANCER; UP-REGULATION; COLON-CANCER;
D O I：
10.3892/ijmm.2021.4888
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The appearance and growth of malignant tumors is a complicated process that is regulated by a number of genes. In recent years, studies have revealed that the transforming growth factor-beta (TGF-beta) signaling pathway serves an important role in cell cycle regulation, growth and development, differentiation, extracellular matrix synthesis and immune response. Notably, two members of the TGF-beta signaling pathway, TGF-beta 1 and TGF-beta receptor 1 (TGF-beta R1), are highly expressed in a variety of tumors, such as breast cancer, colon cancer, gastric cancer and hepatocellular carcinoma. Moreover, an increasing number of studies have demonstrated that TGF-beta 1 and TGF-beta R1 promote proliferation, migration and epithelial-mesenchymal transition of tumor cells by activating other signaling pathways, signaling molecules or microRNAs (miRs), such as the NF-kappa B signaling pathway and miR-133b. In addition, some inhibitors targeting TGF-beta 1 and TGF-beta R1 have exhibited positive effects in in vitro experiments. The present review discusses the association between TGF-beta 1 or TGF-beta R1 and tumors, and the development of some inhibitors, hoping to provide more approaches to help identify novel tumor markers to restrain and cure tumors.
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页数：15
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