Diastereo-and enantioselective synthesis of cis-2-hydroxycyclohexanamine and corresponding ethers by asymmetric reductive amination

被引：23

作者：

Lauktien, G ^{[1
]}

Volk, FJ ^{[1
]}

Frahm, AW ^{[1
]}

机构：

[1] INST PHARMAZEUT,LEHRSTUHL PHARMAZEUT CHEM,D-79104 FREIBURG,GERMANY

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 20期

关键词：

D O I：

10.1016/S0957-4166(97)00456-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of homochiral cis-2-alkoxy- and 2-aryloxycyclohexanamines 5b-5e has been synthesised by means of asymmetric reductive amination of the corresponding racemic 2-oxygenated cyclohexanones 2 with ee-values ranging from 95 to >99%. The respective 2-hydroxy and 2-cyclohexyl derivatives 5g-5h have been prepared from the 2-phenoxycyclohexanamine 4e. Relative and absolute stereochemistry has been elucidated. (C) 1997 Elsevier Science Ltd.

引用

页码：3457 / 3466

页数：10

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