The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease and Related Systemic Diseases

被引：123
作者：
Zhang, Zhiying [1 ]
Liu, Dongjuan [2 ]
Liu, Sai [3 ]
Zhang, Shuwei [1 ]
Pan, Yaping [1 ]
机构：
[1] China Med Univ, Sch & Hosp Stomatol, Dept Periodont, Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R China
[2] China Med Univ, Sch & Hosp Stomatol, Dept Emergency & Oral Med, Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R China
[3] China Med Univ, Sch & Hosp Stomatol, Dept Dent Mat, Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2021年 / 10卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Porphyromonas gingivalis; outer membrane vesicles; virulence factors; periodontal disease; systemic diseases; RHEUMATOID-ARTHRITIS; DIABETES-MELLITUS; EPITHELIAL-CELLS; ASSOCIATION; INVASION; BACTERIA; VIRULENCE; PROTEINS; RELEASE; STEATOHEPATITIS;
D O I：
10.3389/fcimb.2020.585917
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Periodontal disease is a chronic infectious disease associated with a variety of bacteria, which can cause damage to the periodontal support structure and affect a variety of systemic system diseases such as cancer, cardiovascular disease, diabetes, rheumatoid arthritis, non-alcoholic fatty liver, and Alzheimer's disease. Porphyromonas gingivalis (P. gingivalis) is the most important pathogenic bacteria for periodontal disease. It can produce outer membrane vesicles (OMVs) and release them into the environment, playing an important role in its pathogenesis. This article focuses on P. gingivalis OMVs, reviews its production and regulation, virulence components, mode of action and related diseases, with a view to providing new ideas for the prevention and treatment of diseases related to P. gingivalis infections.
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页数：12
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