Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

被引：208

作者：

Coutinho, Diego de Sa ^{[1
]}

Pacheco, Maria Talita ^{[1
]}

Frozza, Rudimar Luiz ^{[2
]}

Bernardi, Andressa ^{[1
]}

机构：

[1] Oswaldo Cruz Fdn FIOCRUZ, Oswaldo Cruz Inst, Lab Inflammat, BR-21040360 Rio De Janeiro, Brazil

[2] Oswaldo Cruz Fdn FIOCRUZ, Oswaldo Cruz Inst, Lab Thymus Res, BR-21040360 Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 06期

关键词：

resveratrol; inflammation; chronic diseases; NF-KAPPA-B; ACTIVATED PROTEIN-KINASE; ACUTE LUNG INJURY; CANCER-RELATED INFLAMMATION; ARTERIAL ENDOTHELIAL-CELLS; LIPID-CORE NANOCAPSULES; INHIBITS PHORBOL ESTER; OXIDATIVE STRESS; MOUSE MODEL; RED WINE;

D O I：

10.3390/ijms19061812

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is well known that unchecked or chronic inflammation becomes deleterious, leading to progressive tissue damage. Studies over the past years focused on foods rich in polyphenols with anti-inflammatory and immunomodulatory properties, since inflammation was recognized to play a central role in several diseases. In this review, we discuss the beneficial effects of resveratrol, the most widely investigated polyphenol, on cancer and neurodegenerative, respiratory, metabolic, and cardiovascular diseases. We highlight how resveratrol, despite its unfavorable pharmacokinetics, can modulate the inflammatory pathways underlying those diseases, and we identify future opportunities for the evaluation of its clinical feasibility.

引用

页数：25

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