THE LET-7 MICRORNA FAMILY UP-REGULATES HEME OXYGENASE-1 BY SUPPRESSING BACH1 AND ATTENUATES OXIDANT INJURY IN HUMAN HEPATOCYTES

被引:0
|
作者
Hou, Weihong [1 ,2 ]
Tian, Qing [1 ]
Li, Ting [1 ]
Bonkovsky, Herbert L. [1 ,2 ]
机构
[1] Carolinas Med Ctr, Canon Res Ctr, Charlotte, NC 28203 USA
[2] Carolinas Med Ctr, Liver Biliary Pancreat Ctr, Charlotte, NC 28203 USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
104
引用
收藏
页码:352A / 353A
页数:2
相关论文
共 50 条
  • [1] The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes
    Hou, Weihong
    Tian, Qing
    Steuerwald, Nury M.
    Schrum, Laura W.
    Bonkovsky, Herbert L.
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2012, 1819 (11-12): : 1113 - 1122
  • [2] Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene
    Sun, JY
    Hoshino, H
    Takaku, K
    Nakajima, O
    Muto, A
    Suzuki, H
    Tashiro, S
    Takahashi, S
    Shibahara, S
    Alam, J
    Taketo, MM
    Yamamoto, M
    Igarashi, K
    EMBO JOURNAL, 2002, 21 (19): : 5216 - 5224
  • [3] Bach1 is a key repressor of heme oxygenase-1 and regulates cell proliferation
    Omura, S
    Dohi, Y
    Igarashi, K
    CIRCULATION, 2004, 110 (17) : 277 - 277
  • [4] Hemoprotein BACH1 regulates enhancer accessibility of heme oxygenase-1 gene.
    Sun, JY
    Muto, A
    Suzuki, H
    Nakajima, O
    Yamamoto, M
    Igarashi, K
    BLOOD CELLS MOLECULES AND DISEASES, 2003, 31 (01) : 146 - 147
  • [5] Bach1 is a key-repressor of heme oxygenase-1 and regulates cell proliferation
    Omura, S
    Sun, JY
    Suzuki, H
    Igarashi, K
    CIRCULATION, 2003, 108 (17) : 291 - 291
  • [6] Bach1 is a key-repressor of heme oxygenase-1 and regulates cell proliferation
    Omura, S
    Sun, JY
    Suzuki, H
    Igarashi, K
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (05) : 506A - 506A
  • [7] MiR-196a regulates heme oxygenase-1 by silencing Bach1 in the neonatal mouse lung
    Go, Hayato
    La, Ping
    Namba, Fumihiko
    Ito, Masato
    Yang, Guang
    Brydun, Andrey
    Igarashi, Kazuhiko
    Dennery, Phyllis A.
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016, 311 (02) : L400 - L411
  • [8] Synergistic up-regulation of heme oxygenase-1 in human liver by heme and siRNA to Bach1: Possible therapeutic implications.
    Ghaziani, T
    Shan, Y
    Lambrecht, RW
    Bonkovsky, HL
    BLOOD, 2004, 104 (11) : 454A - 454A
  • [9] Bach1, a transcriptional repressor of heme oxygenase-1, is a novel therapeutic target for ischemic myocardial injury
    Yano, Y
    Ozono, R
    Oishi, Y
    Kambe, M
    Omura, S
    Igarashi, K
    Oshima, T
    HYPERTENSION, 2003, 42 (03) : 390 - 390
  • [10] Hepatitis C proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of BACH1 in human hepatocytes.
    Ghaziani, T
    Shan, Y
    Lambrecht, RW
    Pietschman, T
    Bartenschlager, R
    Bonkovsky, HL
    HEPATOLOGY, 2004, 40 (04) : 453A - 453A