Low-dose Clozapine-induced Seizure: A Case Report

被引：15

作者：

Bolu, Abdullah ^{[1
]}

Akarsu, Suleyman ^{[2
]}

Pan, Erdal ^{[1
]}

Aydemir, Emre ^{[3
]}

Oznur, Taner ^{[4
]}

机构：

[1] Aircrews Hlth Res & Training Ctr, Eskisehir, Turkey

[2] Iskenderun Mil Hosp, Dept Psychiat, Ibrahim Karaoglanoglu St, TR-31200 Iskenderun, Hatay, Turkey

[3] Beytepe Mil Hosp, Dept Psychiat, Ankara, Turkey

[4] Gulhane Mil Med Fac, Dept Psychiat, Ankara, Turkey

来源：

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | 2017年 / 15卷 / 02期

关键词：

Clozapine; Adverse effects; Seizures; Safety; EEG ABNORMALITIES; CLINICAL-RESPONSE; RECEPTORS; SCHIZOPHRENIA; OLANZAPINE; NEURONS;

D O I：

10.9758/cpn.2017.15.2.190

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Seizures are believed to be a dose-dependent side effect of clozapine. In this case report, we describe a patient who had tonic-clonic seizures after using a low dose clozapine who did not have any seizure risk. The 29-year-old male patient had been followed-up with a diagnosis of schizophrenia for about 5 years. When using clozapine 200 mg/day he had a tonic-clonic seizure with bilateral diffuse epileptic activity in electroencephalography (EEG). In the literature, there are a few case reports about low-dose clozapine-induced seizure. Seizures were observed in our case with a low dose of clozapine (200 mg/day) making this case remarkable. EEG monitoring at regular intervals and examination of plasma levels of clozapine could be useful in preventing the development of seizures.

引用

页码：190 / 193

页数：4

共 33 条

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