Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes

被引：81

作者：

Wen, Wangrong ^{[1
]}

Iwakiri, Dal ^{[1
]}

Yamamoto, Koji ^{[1
]}

Maruo, Seiji ^{[1
]}

Kanda, Teru ^{[1
]}

Takada, Kenzo ^{[1
]}

机构：

[1] Hokkaido Univ, Dept Tumor Virol, Inst Med Genet, Kita Ku, Sapporo, Hokkaido 0600815, Japan

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 02期

关键词：

D O I：

10.1128/JVI.01416-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We demonstrate here that the Epstein-Barr virus (EBV) BZLF1 gene, a switch from latent infection to lytic infection, is expressed as early as 1.5 h after EBV infection in Burkitt's lymphoma-derived, EBV-negative Akata and Daudi cells and primary B lymphocytes. Since BZLF1 mRNA is expressed even when the cells are infected with EBV in the presence of anisomycin, an inhibitor of protein synthesis, its expression does not require prerequisite protein synthesis, indicating that BZLF1 is expressed as an immediate-early gene following primary EBV infection of B lymphocytes.

引用

页码：1037 / 1042

页数：6

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