Impaired Fellow Eye Motion Perception and Abnormal Binocular Function

被引:22
作者
Birch, Eileen E. [1 ,2 ]
Jost, Reed M. [1 ]
Wang, Yi-Zhong [1 ]
Kelly, Krista R. [1 ]
Giaschi, Deborah E. [3 ]
机构
[1] Retina Fdn Southwest, Crystal Char Ball Pediat Vis Lab, Dallas, TX USA
[2] UT Southwestern Med Ctr, Dept Ophthalmol, Dallas, TX USA
[3] Univ British Columbia, Dept Ophthalmol & Visual Sci, Vancouver, BC, Canada
关键词
amblyopia; binocular vision; motion perception; DEFINED FORM; AMBLYOPIA; CHILDREN; DISCRIMINATION; STEREOACUITY; SUPPRESSION; DEFICITS; THERAPY; NEURONS; V2;
D O I
10.1167/iovs.19-26885
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE. Binocular discordance due to strabismus, anisometropia, or both may result in not only monocular visual acuity deficits, but also in motion perception deficits. We determined the prevalence of fellow-eye deficits in motion-defined form (MDF) perception, the ability to identify a two-dimensional (2D) shape defined by motion rather than luminance contrast. We also examined the following: the causative role of reduced visual acuity and binocularity, associations with clinical and sensory factors, and effectiveness of binocular amblyopia treatment in alleviating deficits. METHODS. Participants included 91 children with residual amblyopia (strabismic, anisometropic, or both; age, 9.0 +/- 1.7 years), 79 nonamblyopic children with treated strabismus or anisometropia (age, 8.5 +/- 2.1 years), and 20 controls (age, 8.6 +/- 1.5 years). MDF coherence thresholds, visual acuity, stereoacuity, and interocular suppression were measured. RESULTS. MDF deficits, relative to controls, were present in the fellow eye of 23% of children with residual amblyopia and 20% of nonamblyopic children. Stereoacuity and age first patched were correlated with MDF threshold (r = 0.29, 95% CI: 0.09-0.47; r = -0.33, 95% CI: -0.13 to -0.50, respectively). MDF deficits were more common in children treated with patching alone than in those receiving contrast-rebalanced binocular treatment with games or movies (t(89) = 3.46; P = 0.0008). The latter was associated with a reduction in mean fellow eye MDF threshold (t(26) = 6.32, P < 0.0001). CONCLUSIONS. Fellow eye MDF deficits are common and likely reflect abnormalities in binocular cortical mechanisms that result from early discordant visual experience. Binocular amblyopia treatment, which is effective in improving amblyopic eye visual acuity, appears to provide a benefit for the fellow eye.
引用
收藏
页码:3374 / 3380
页数:7
相关论文
共 31 条
[1]   Binocular amblyopia treatment with contrast-rebalanced movies [J].
Birch, Eileen E. ;
Jost, Reed M. ;
De La Cruz, Angie ;
Kelly, Krista R. ;
Beauchamp, Cynthia L. ;
Dao, Lori ;
Stager, David, Jr. ;
Leffler, Joel N. .
JOURNAL OF AAPOS, 2019, 23 (03) :160-162
[2]   Assessing Suppression in Amblyopic Children With a Dichoptic Eye Chart [J].
Birch, Eileen E. ;
Morale, Sarah E. ;
Jost, Reed M. ;
De La Cruz, Angie ;
Kelly, Krista R. ;
Wang, Yi-Zhong ;
Bex, Peter J. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (13) :5649-5654
[3]   Amblyopia and binocular vision [J].
Birch, Eileen E. .
PROGRESS IN RETINAL AND EYE RESEARCH, 2013, 33 :67-84
[4]   Form and motion coherence activate independent, but not dorsal/ventral segregated, networks in the human brain [J].
Braddick, OJ ;
O'Brien, JMD ;
Wattam-Bell, J ;
Atkinson, J ;
Turner, R .
CURRENT BIOLOGY, 2000, 10 (12) :731-734
[5]   Visual Motion Processing by Neurons in Area MT of Macaque Monkeys with Experimental Amblyopia [J].
El-Shamayleh, Yasmine ;
Kiorpes, Lynne ;
Kohn, Adam ;
Movshon, J. Anthony .
JOURNAL OF NEUROSCIENCE, 2010, 30 (36) :12198-12209
[6]   Development of motion-defined figure ground segregation in preschool and older children, using a letter-identification task [J].
Giaschi, D ;
Regan, D .
OPTOMETRY AND VISION SCIENCE, 1997, 74 (09) :761-767
[7]  
GIASCHI DE, 1992, INVEST OPHTH VIS SCI, V33, P2483
[8]   The effect of occlusion therapy on motion perception deficits in amblyopia [J].
Giaschi, Deborah ;
Chapman, Christine ;
Meier, Kimberly ;
Narasimhan, Sathyasri ;
Regan, David .
VISION RESEARCH, 2015, 114 :122-134
[9]  
Glaser SR, 2002, ARCH OPHTHALMOL-CHIC, V120, P268
[10]   Effects of speed, age, and amblyopia on the perception of motion-defined form [J].
Hayward, Jake ;
Truong, Grace ;
Partanen, Marita ;
Giaschi, Deborah .
VISION RESEARCH, 2011, 51 (20) :2216-2223