The impact of cell-of-origin, MYC/Bcl-2 dual expression and MYC rearrangement on disease relapse among early stage diffuse large B-cell lymphoma patients treated with combined modality therapy

被引：10

作者：

Augustyn, Alexander ^{[1
]}

Medeiros, L. Jeffrey ^{[2
]}

Ludmir, Ethan B. ^{[1
]}

Gunther, Jillian ^{[1
]}

Fang, Penny ^{[1
]}

Li, Shaoying ^{[2
]}

Ok, Chi Young ^{[2
]}

Bankston, Mikaela E. ^{[1
]}

Verma, Vivek ^{[3
]}

Pasalic, Dario ^{[1
]}

Ahmed, Sairah ^{[4
]}

Nastoupil, Loretta J. ^{[4
]}

Westin, Jason R. ^{[4
]}

Strati, Paolo ^{[4
]}

Neelapu, Sattva S. ^{[4
]}

Nair, Ranjit ^{[4
]}

Steiner, Raphael E. ^{[4
]}

Iyer, Swaminathan P. ^{[4
]}

Rodriguez, Alma ^{[4
]}

Fayad, Luis E. ^{[4
]}

Flowers, Christopher R. ^{[4
]}

Dabaja, Bouthaina S. ^{[1
]}

Pinnix, Chelsea C. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Unit 97,1515 Holcombe Blvd, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

[3] Allegheny Gen Hosp, Dept Radiat Oncol, Pittsburgh, PA 15212 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA

来源：

LEUKEMIA & LYMPHOMA | 2021年 / 62卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Lymphoma; MYC; BCL2; immunophenotype; consolidative radiation; diffuse large B-cell lymphoma;

D O I：

10.1080/10428194.2020.1869965

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We addressed the prognostic impact of cell-of-origin (COO), MYC and Bcl-2 overexpression as well as isolated MYC rearrangement among 111 patients with limited stage diffuse large B-cell lymphoma (DLBCL) treated with consolidative radiation therapy (RT) after a metabolic complete response to immunochemotherapy. With a median follow-up of 31.1 months (95% CI 27.4 - 34.8), 4 relapses occurred. The 3-year progression free survival (PFS), overall survival (OS), and loco-regional relapse free survival (LRFS) for the cohort were 95%, 96%, and 100%, respectively. There were no differences in OS, PFS, or LRFS based on COO or MYC/Bcl-2 dual expression (DE). Similarly, patients with MYC translocations without BCL2 or BCL6 rearrangements did not have worse outcomes. Consolidative RT produced excellent local control, regardless of DLBCL biology, with one late in-field failure.

引用

页码：1361 / 1369

页数：9

共 28 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] COO and MYC/BCL2 status do not predict outcome among patients with stage I/II DLBCL: a retrospective multicenter study [J].

Barraclough, Allison ;

Alzahrani, Musa ;

Ettrup, Marianne Schmidt ;

Bishton, Mark ;

van Vliet, Chris ;

Farinha, Pedro ;

Gould, Clare ;

Birch, Simone ;

Sehn, Laurie H. ;

Sovani, Vishakha ;

Ward, Mitchell Steven ;

Augustson, Bradley ;

Biccler, Jorne ;

Connors, Joseph M. ;

Scott, David W. ;

Gandhi, Maher K. ;

Savage, Kerry J. ;

El-Galaly, Tarec ;

Villa, Diego ;

Cheah, Chan Yoon .

BLOOD ADVANCES, 2019, 3 (13) :2013-2021

[3] A clinician's guide to double hit lymphomas [J].

Cheah, Chan Yoon ;

Oki, Yasuhiro ;

Westin, Jason R. ;

Turturro, Francesco .

BRITISH JOURNAL OF HAEMATOLOGY, 2015, 168 (06) :784-795

[4] Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification [J].

Cheson, Bruce D. ;

Fisher, Richard I. ;

Barrington, Sally F. ;

Cavalli, Franco ;

Schwartz, Lawrence H. ;

Zucca, Emanuele ;

Lister, T. Andrew .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) :3059-+

[5] Reduced Treatment Intensity in Patients with Early-Stage Hodgkin's Lymphoma [J].

Engert, Andreas ;

Pluetschow, Annette ;

Eich, Hans Theodor ;

Lohri, Andreas ;

Doerken, Bernd ;

Borchmann, Peter ;

Berger, Bernhard ;

Greil, Richard ;

Willborn, Kay C. ;

Wilhelm, Martin ;

Debus, Juergen ;

Eble, Michael J. ;

Soekler, Martin ;

Ho, Antony ;

Rank, Andreas ;

Ganser, Arnold ;

Truemper, Lorenz ;

Bokemeyer, Carsten ;

Kirchner, Hartmut ;

Schubert, Joerg ;

Kral, Zdenek ;

Fuchs, Michael ;

Mueller-Hermelink, Hans-Konrad ;

Mueller, Rolf-Peter ;

Diehl, Volker .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (07) :640-652

[6] Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group [J].

Fuchs, Michael ;

Goergen, Helen ;

Kobe, Carsten ;

Kuhnert, Georg ;

Lohri, Andreas ;

Greil, Richard ;

Sasse, Stephanie ;

Topp, Max S. ;

Schaefer, Erhardt ;

Hertenstein, Bernd ;

Soekler, Martin ;

Vogelhuber, Martin ;

Zijlstra, Josee M. ;

Keller, Ulrich Bernd ;

Krause, Stefan W. ;

Wilhelm, Martin ;

Maschmeyer, Georg ;

Thiemer, Julia ;

Duehrsen, Ulrich ;

Meissner, Julia ;

Viardot, Andreas ;

Eich, Hans ;

Baues, Christian ;

Diehl, Volker ;

Rosenwald, Andreas ;

von Tresckow, Bastian ;

Dietlein, Markus ;

Borchmann, Peter ;

Engert, Andreas .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (31) :2835-+

[7] Diffuse Large B-Cell Lymphoma Should Limited-Stage Patients Be Treated Differently? [J].

Gine, Eva ;

Sehn, Laurie H. .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2016, 30 (06) :1179-+

[8] Radiotherapy for early stage diffuse large B-cell lymphoma with or without double or triple hit genetic alterations [J].

Grass, George Daniel ;

Mills, Matthew N. ;

Ahmed, Kamran A. ;

Liveringhouse, Casey L. ;

Montejo, Michael J. ;

Robinson, Timothy J. ;

Chavez, Julio C. ;

Harrison, Louis B. ;

Kim, Sungjune .

LEUKEMIA & LYMPHOMA, 2019, 60 (04) :886-893

[9] Immunohistochemical Double-Hit Score Is a Strong Predictor of Outcome in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone [J].

Green, Tina Marie ;

Young, Ken H. ;

Visco, Carlo ;

Xu-Monette, Zijun Y. ;

Orazi, Attilio ;

Go, Ronald S. ;

Nielsen, Ole ;

Gadeberg, Ole V. ;

Mourits-Andersen, Torben ;

Frederiksen, Mikael ;

Pedersen, Lars Moller ;

Moller, Michael Boe .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (28) :3460-3467

[10] Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy [J].

Gutierrez-Garcia, Gonzalo ;

Cardesa-Salzmann, Teresa ;

Climent, Fina ;

Gonzalez-Barca, Eva ;

Mercadal, Santiago ;

Mate, Jose L. ;

Sancho, Juan M. ;

Arenillas, Leonor ;

Serrano, Sergi ;

Escoda, Lourdes ;

Martinez, Salome ;

Valera, Alexandra ;

Martinez, Antonio ;

Jares, Pedro ;

Pinyol, Magdalena ;

Garcia-Herrera, Adriana ;

Martinez-Trillos, Alejandra ;

Gine, Eva ;

Villamor, Neus ;

Campo, Elias ;

Colomo, Luis ;

Lopez-Guillermo, Armando .

BLOOD, 2011, 117 (18) :4836-4843

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