1H, 13C and 15N resonance assignments for the tandem CUE domains from chromatin remodeler SMARCAD1

被引：1

作者：

Biasutto, Antonio J. ^{[1
,2
]}

West, Philip M. ^{[2
]}

Mancini, Erika J. ^{[2
,3
]}

Redfield, Christina ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, South Parks Rd, Oxford OX1 3QU, England

[2] Univ Oxford, Div Struct Biol, Henry Wellcome Bldg Genom Med,Roosevelt Dr, Oxford OX3 7BN, England

[3] Univ Sussex, Sch Life Sci, Biomed & Biochem Dept, Brighton BN1 9QG, E Sussex, England

来源：

BIOMOLECULAR NMR ASSIGNMENTS | 2019年 / 13卷 / 02期

基金：

英国惠康基金;

关键词：

CUE domain; SMARCAD1; Chromatin remodelling; ATPase; NMR resonance assignments; Secondary structure; FUN30; RESECTION;

D O I：

10.1007/s12104-019-09888-9

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

SMARCAD1 is a non-canonical chromatin remodelling ATPase, unique in its domain organization in that is encodes tandem ubiquitin binding CUE domains along with a classical SNF2 helicase ATP-dependent motor. SMARCAD1 is conserved from yeast to humans and has reported roles in the maintenance of heterochromatin following replication and in double-strand break repair. Here we present the H-1, C-13 and N-15 assignments for the tandem CUE domains and for the disordered regions that flank them. These assignments provide the starting point for detailed investigations of the structure and interactions of this region of SMARCAD1.

引用

页码：261 / 265

页数：5

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