First asymmetric total synthesis of aspinolide A

被引：28

作者：

Chowdhury, Partha Sarathi ^{[1
]}

Gupta, Priti ^{[1
]}

Kumar, Pradeep ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 50期

关键词：

Decanolides; Hydrolytic kinetic resolution; Ring-closing metathesis; Epoxides; HYDROLYTIC KINETIC RESOLUTION; EFFICIENT TOTAL-SYNTHESIS; DIMETHYLSULFONIUM METHYLIDE; ENANTIOSELECTIVE SYNTHESIS; TERMINAL EPOXIDES; ORGANIC-SYNTHESIS; CONCISE SYNTHESIS; ALCOHOLS;

D O I：

10.1016/j.tetlet.2009.09.151

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of aspinolide A has been achieved using ring-closing metathesis as a key step. The stereogenic centers were generated by means of hydrolytic kinetic resolution (HKR) of racemic epoxides. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：7018 / 7020

页数：3

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