Transposition: A CRISPR Way to Get Around

被引：3

作者：

Dimitriu, Tatiana ^{[1
]}

Ashby, Ben ^{[2
]}

Westra, Edze R. ^{[1
]}

机构：

[1] Univ Exeter, Biosci, Environm & Sustainabil Inst, Cornwall Campus, Penryn TR10 9FE, Cornwall, England

[2] Univ Bath, Dept Math Sci, Claverton Down, Bath BA2 7AY, Somerset, England

来源：

CURRENT BIOLOGY | 2019年 / 29卷 / 18期

关键词：

CAS SYSTEMS; RESISTANCE; GENOME; RNA;

D O I：

10.1016/j.cub.2019.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CRISPR-Cas systems provide sequence-specific immunity against selfish genetic elements in prokaryotes. Now, two studies show that transposon-encoded variants can guide sequence-specific transposition. These findings have important practical implications but also raise questions of why and how this strategy would benefit transposons.

引用

收藏

页码：R886 / R889

页数：5

相关论文

共 20 条

[1] CRISPR provides acquired resistance against viruses in prokaryotes [J].

Barrangou, Rodolphe ;

Fremaux, Christophe ;

Deveau, Helene ;

Richards, Melissa ;

Boyaval, Patrick ;

Moineau, Sylvain ;

Romero, Dennis A. ;

Horvath, Philippe .

SCIENCE, 2007, 315 (5819) :1709-1712

[2] Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system [J].

Bondy-Denomy, Joe ;

Pawluk, April ;

Maxwell, Karen L. ;

Davidson, Alan R. .

NATURE, 2013, 493 (7432) :429-U181

[3] Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity [J].

Borges, Adair L. ;

Zhang, Jenny Y. ;

Rollins, MaryClare F. ;

Osuna, Beatriz A. ;

Wiedenheft, Blake ;

Bondy-Denomy, Joseph .

CELL, 2018, 174 (04) :917-+

[4] Small CRISPR RNAs guide antiviral defense in prokaryotes [J].

Brouns, Stan J. J. ;

Jore, Matthijs M. ;

Lundgren, Magnus ;

Westra, Edze R. ;

Slijkhuis, Rik J. H. ;

Snijders, Ambrosius P. L. ;

Dickman, Mark J. ;

Makarova, Kira S. ;

Koonin, Eugene V. ;

van der Oost, John .

SCIENCE, 2008, 321 (5891) :960-964

[5] THE POPULATION BIOLOGY OF BACTERIAL TRANSPOSONS - A PRIORI CONDITIONS FOR MAINTENANCE AS PARASITIC DNA [J].

CONDIT, R ;

STEWART, FM ;

LEVIN, BR .

AMERICAN NATURALIST, 1988, 132 (01) :129-147

[6] Phage response to CRISPR-Encoded resistance in Streptococcus thermophilus [J].

Deveau, Helene ;

Barrangou, Rodolphe ;

Garneau, Josiane E. ;

Labonte, Jessica ;

Fremaux, Christophe ;

Boyaval, Patrick ;

Romero, Dennis A. ;

Horvath, Philippe ;

Moineau, Sylvain .

JOURNAL OF BACTERIOLOGY, 2008, 190 (04) :1390-1400

[7] CRISPR-Cas in mobile genetic elements: counter-defence and beyond [J].

Faure, Guilhem ;

Shmakov, Sergey A. ;

Yan, Winston X. ;

Cheng, David R. ;

Scott, David A. ;

Peters, Joseph E. ;

Makarova, Kira S. ;

Koonin, Eugene, V .

NATURE REVIEWS MICROBIOLOGY, 2019, 17 (08) :513-525

[8] Transposon Tn7 directs transposition into the genome of filamentous bacteriophage M13 using the element-encoded TnsE protein [J].

Finn, Jessica A. ;

Parks, Adam R. ;

Peters, Joseph E. .

JOURNAL OF BACTERIOLOGY, 2007, 189 (24) :9122-9125

[9] Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration [J].

Klompe, Sanne E. ;

Vo, Phuc L. H. ;

Halpin-Healy, Tyler S. ;

Sternberg, Samuel H. .

NATURE, 2019, 571 (7764) :219-+

[10] Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity [J].

Landsberger, Mariann ;

Gandon, Sylvain ;

Meaden, Sean ;

Rollie, Clare ;

Chevallereau, Anne ;

Chabas, Helene ;

Buckling, Angus ;

Westra, Edze R. ;

van Houte, Stineke .

CELL, 2018, 174 (04) :908-+