Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort

被引：15

作者：

Agliardi, Cristina ^{[1
]}

Guerini, Franca Rosa ^{[1
]}

Zanzottera, Milena ^{[1
]}

Bolognesi, Elisabetta ^{[1
]}

Costa, Andrea Saul ^{[1
]}

Clerici, Mario ^{[1
,2
]}

机构：

[1] Fdn Don C Gnocchi, IRCCS, Piazza Morandi 3, I-20121 Milan, Italy

[2] Univ Milan, Dept Biomed Sci & Technol, Via Fill Cervi 93, I-20090 Milan, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 305卷

关键词：

Multiple sclerosis; Vitamin D; DBP; Gc; Polymorphism; SNP; GROUP-SPECIFIC COMPONENT; OBSTRUCTIVE PULMONARY-DISEASE; MULTIPLE-SCLEROSIS SEVERITY; 25-HYDROXYVITAMIN D LEVELS; GENOME-WIDE ASSOCIATION; METAANALYSIS; GC; DETERMINANTS; PROGRESSION; DISABILITY;

D O I：

10.1016/j.jneuroim.2017.02.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitamin D binding protein (DBP) gene encodes for Gc, an alpha(2) globulin that transports vitamin D metabolites in serum. Given the role of vitamin D in MS onset and disease progression we analyzed the frequencies of three polymorphisms (rs7041, rs4588 and rs2282679) within DBP gene in 701 Italian multiple sclerosis (MS) patients and 831 healthy controls (HC). None of the polymorphisms showed any association with MS onset and progression. Our results suggest that DBP is not involved in the pathogenesis of MS in Italians. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：92 / 95

页数：4

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