Synthesis of a novel ring-expanded purine analogue containing a 5:8-fused imidazo[4,5-e][1,2,4]triazocine ring system amidst opportunistic rearrangements and ring transformations

被引：3
作者：
Burnett, FN [1 ]
Hosmane, RS [1 ]
机构：
[1] Univ Maryland, Lab Drug Design & Synth, Dept Chem & Biochem, Baltimore, MD 21250 USA
来源：
TETRAHEDRON | 2002年 / 58卷 / 47期
基金：
美国国家卫生研究院;
关键词：
ring-expanded purine; ring transformations; 5 : 8-fused; heterocycles; rearrangements;
D O I：
10.1016/S0040-4020(02)01252-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel 5:8-fused heterocycle containing the imidazo[4,5-e][1,2,4]triazocine ring system has been synthesized in ten steps commencing from 1-benzyl-5-methyl-4-nitroimidazole. The compound is a new member of the family of ring-expanded xanthine-xanthosine analogues reported from this laboratory. The synthesis led to the unraveling of a number of novel rearrangements and ring-transformations. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：9567 / 9578
页数：12
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