An In Vivo Confocal Microscopic Study of Corneal Nerve Morphology in Unilateral Keratoconus

被引:17
作者
Pahuja, Natasha Kishore [1 ]
Shetty, Rohit [1 ]
Nuijts, Rudy M. M. A. [2 ]
Agrawal, Aarti [1 ]
Ghosh, Arkasubhra [1 ]
Jayadev, Chaitra [1 ]
Nagaraja, Harsha [1 ]
机构
[1] Narayana Nethralaya Eye Hosp, Bangalore 560010, Karnataka, India
[2] Maastricht Univ, Acad Hosp, POB 616, NL-6200 MD Maastricht, Netherlands
关键词
DIAGNOSIS; DENSITY; DISEASE; HEALTH; LIGHT; EYES;
D O I
10.1155/2016/5067853
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Purpose. To study the corneal nerve morphology and its importance in unilateral keratoconus. Materials and Methods. In this prospective cross-sectional study, 33 eyes of 33 patients with keratoconus in one eye (Group 3) were compared with the other normal eye of the same patients (Group 2) and 30 eyes of healthy patients (Group 1). All patients underwent detailed ophthalmic examination followed by topography with Pentacam HR and in vivo confocal microscopy (IVCM). Five images obtained with IVCM were analyzed using an automated CCmetrics software version 1.0 for changes in subbasal plexus of nerves. Results. Intergroup comparison showed statistically significant reduction in corneal nerve fiber density (CNFD) and length (CNFL) in Group 3 as compared to Group 1 (p < 0.001 and p = 0.001, resp.) and Group 2 (p = 0.01 and p = 0.02, resp.). Though corneal nerve fiber length, diameter, area, width, corneal nerve branch density, and corneal total branch density were found to be higher in decentered cones, only the corneal nerve branch density (CNBD) was found to be statistically significant (p < 0.01) as compared to centered cones. Conclusion. Quantitative changes in the corneal nervemorphology can be used as an imaging marker for the early diagnosis of keratoconus before the onset of refractive or topography changes.
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页数:5
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